Li Ruiyu, Gao Yin, Song Ting, Li Nan, Deng Rui, Jiao Feng, Yan Chaofang, Chen Ying
Yunnan Provincial Key Laboratory of Public Health and Biosafety & School of Public Health, Kunming Medical University, Kunming, 650500, Yunnan, China.
Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development, Kunming, 650500, Yunnan, China.
AIDS Res Ther. 2025 Aug 30;22(1):86. doi: 10.1186/s12981-025-00776-y.
The diversity of HIV-1 genotypes among Men who have sex with men (MSM) globally has changed considerably. The purpose of this study to assess the global prevalence of HIV-1 genotypes among MSM.
PubMed, Embase, Scopus, and Web of Science were systematically searched to identify the articles. Pooled prevalence of HIV-1 genotypes was calculated and subgroup analyses were performed to examine the prevalence estimates across time and locations.
A total of 95 studies were included in the final analysis, including 84,622 successfully genotyped samples. The predominant strains were CRF01_AE (34.46%), subtype B (31.16%), and CRF07_BC (24.72%). In subgroup analyses, Subtype B and C showed a declining trend over the years. However, CRF07_BC exhibited a consistent year-on-year increase, while CRF01_AE experienced a slight reduction after 2018. Notably, both subtypes currently account for more than 35% of the total. In addition, the distribution of HIV-1 subtypes in this population shown a clear regional distribution. Regionally, subtype B predominated in Latin America and Europe, CRF01_AE and CRF07_BC in Asia and China, while subtype C and CRF02_AG were dominant in Africa and the Middle East.
Global and regions MSM HIV-1 subtypes are becoming more complex over time and the prevalence of recombinant viruses is increasing. Ongoing and effective surveillance of the global and regional molecular epidemiology of HIV-1 in MSM is critical for developing targeted preventive control measures against HIV.
全球男男性行为者（MSM）中HIV-1基因型的多样性发生了显著变化。本研究旨在评估MSM中HIV-1基因型的全球流行情况。
系统检索PubMed、Embase、Scopus和Web of Science以识别相关文章。计算HIV-1基因型的合并流行率，并进行亚组分析以检验不同时间和地点的流行率估计值。
最终分析共纳入95项研究，包括84,622个成功进行基因分型的样本。主要毒株为CRF01_AE（34.46%）、B亚型（31.16%）和CRF07_BC（24.72%）。在亚组分析中，B亚型和C亚型多年来呈下降趋势。然而，CRF07_BC呈逐年持续上升，而CRF01_AE在2018年后略有下降。值得注意的是，这两种亚型目前占总数的35%以上。此外，该人群中HIV-1亚型的分布呈现出明显的区域分布。在区域上，B亚型在拉丁美洲和欧洲占主导地位，CRF01_AE和CRF07_BC在亚洲和中国占主导地位，而C亚型和CRF02_AG在非洲和中东占主导地位。
随着时间的推移，全球和各地区MSM的HIV-1亚型变得更加复杂，重组病毒的流行率正在上升。持续有效地监测MSM中HIV-1的全球和区域分子流行病学对于制定针对性的HIV预防控制措施至关重要。
