Germanà B, Di Mario F, Vianello F, Dotto P, Faggian D, Plebani M, Saggioro A, Naccarato R
Cattedra di Malattie dell'Apparato Digerente, Università di Padova.
G Clin Med. 1990 Aug-Sep;71(8-9):493-5.
Several studies have shown an influence of cigarette smoking on serum pepsinogen group I (PGI) levels in duodenal ulcer patients and in control subjects. The elevation of PGI in smokers has just been interpreted as reflecting some degree of smoking-induced inflammation of the gastric mucosa. We have determined fasting serum PGI by radioimmunoassay in 163 healthy subjects investigated by a survey conducted on a sample population of an urban area in the North-East of Italy by means of a random selection based on the public registers of home addresses. The data reported confirmed that PGI levels are increased by smoking in a healthy population. The main contribution of this study consists in demonstrating in a non-selected population an increase of the only parameter up to date claimed to be a possible serological predictive index for ulcer disease.
多项研究表明，吸烟对十二指肠溃疡患者和对照受试者的血清Ⅰ型胃蛋白酶原（PGI）水平有影响。吸烟者PGI升高仅被解释为反映了吸烟引起的某种程度的胃黏膜炎症。我们通过放射免疫分析法测定了163名健康受试者的空腹血清PGI，这些受试者是通过对意大利东北部一个市区的样本人群进行调查，根据家庭住址公共登记册随机选择的。报告的数据证实，健康人群中吸烟会使PGI水平升高。本研究的主要贡献在于，在一个未经过筛选的人群中证明了，迄今为止唯一一个被认为可能是溃疡病血清学预测指标的参数出现了升高。
