Scuto S, Ghinelli C, Rollo S, Mori M, Palummeri E
Pediatr Med Chir. 1986 Nov-Dec;8(6):889-92.
Serum pepsinogen I (PGI) was measured by radioimmunoassay in the fasting state in three homogeneous family groups composed of parents and their children. Group 1, families, did not suffer from primary duodenal ulcer (PDU). Group 2, 10 families had at least one parent with PDU diagnosed endoscopically. Group 3, 6 families, had at least one child with PDU and one parent with PDU diagnosed endoscopically. The analysis of variance (ANOVA) of PGI in the examined children, showed a significant difference between the three groups (F = 22.83; p = 0.005). In all 3 groups the ANOVA of serum PGI of the fathers and the mothers were significantly different: fathers (F = 4.4; p = 0.241); mothers (F = 3.4; p = 0.05). A correlation was noted between PGI of the fathers and PGI of the children (r = 0.31; p = 0.05); but a more significant correlation was observed between PGI of the mothers and PGI of the children (r = 0.48; p = 0.001). In group 3, the correlation between PGI of the mothers and PGI of the children was striking (r = 0.89; p = 0.025). However, the PGI of the fathers and the PGI of the children were not different in this group (r = 0.27; p = n.s.). The multiple correlation between PGI of the children and PGI of both parents was significant (r2 = 0.316). In group 3, the correlation was very high between the mothers and the children (r2 = 0.81).
在空腹状态下，采用放射免疫分析法对由父母及其子女组成的三个同质性家庭组进行血清胃蛋白酶原I（PGI）检测。第1组家庭未患原发性十二指肠溃疡（PDU）。第2组有10个家庭，至少有一位经内镜诊断患有PDU的父母。第3组有6个家庭，至少有一个患有PDU的子女和一位经内镜诊断患有PDU的父母。对受检儿童PGI的方差分析显示，三组之间存在显著差异（F = 22.83；p = 0.005）。在所有3组中，父亲和母亲血清PGI的方差分析也存在显著差异：父亲（F = 4.4；p = 0.241）；母亲（F = 3.4；p = 0.05）。观察到父亲的PGI与子女的PGI之间存在相关性（r = 0.31；p = 0.05）；但母亲的PGI与子女的PGI之间的相关性更为显著（r = 0.48；p = 0.001）。在第3组中，母亲的PGI与子女的PGI之间的相关性尤为显著（r = 0.89；p = 0.025）。然而，在该组中父亲的PGI与子女的PGI并无差异（r = 0.27；p = 无统计学意义）。子女的PGI与父母双方的PGI之间的多重相关性显著（r2 = 0.316）。在第3组中，母亲与子女之间的相关性非常高（r2 = 0.81）。
