Department of Neurosurgery, Wits Medical School, Chris Hani Baragwanath Academic Hospital, 7 York Road, Parktown, Johannesburg 2193, South Africa.
J Clin Neurosci. 2012 Nov;19(11):1589-91. doi: 10.1016/j.jocn.2011.09.037. Epub 2012 Jul 15.
Dural-based brain tumours, apart from meningiomas, are rare. Epstein-Barr virus (EBV)-associated smooth muscle tumor (SMT) is a documented but rare disease that occurs in immunocompromized patients. These tumours may be located at unusual sites including the brain. We present a 37-year-old patient, positive for the human immunodeficiency virus (HIV), who was admitted after generalized tonic-clonic seizures. MRI and CT scan revealed a dural-based brain tumour, intraoperatively thought to be a meningioma, but with an eventual histological diagnosis of EBV-SMT. Clinically the patient was well postoperatively with a Glasgow coma scale score of 15/15 and no focal neurologic deficit. This case confirms the association between EBV and SMT in patients with HIV/acquired immunodeficiency syndrome (AIDS). It also highlights the need to include EBV-SMT in the differential diagnosis of intracranial mass lesions in patients with HIV/AIDS.
除脑膜瘤外，硬脑膜起源的脑肿瘤较为少见。EB 病毒（EBV）相关平滑肌肿瘤（SMT）是一种已被证实但罕见的疾病，发生于免疫功能低下的患者。这些肿瘤可能发生在不常见的部位，包括大脑。我们报告了一位 37 岁的人类免疫缺陷病毒（HIV）阳性患者，因全身强直阵挛性发作而入院。MRI 和 CT 扫描显示硬脑膜起源的脑肿瘤，术中考虑为脑膜瘤，但最终的组织学诊断为 EBV-SMT。术后患者临床状况良好，格拉斯哥昏迷量表评分为 15/15，无局灶性神经功能缺损。该病例证实了 HIV/获得性免疫缺陷综合征（AIDS）患者中 EBV 与 SMT 之间的关联。它还强调了在 HIV/AIDS 患者的颅内肿块病变鉴别诊断中需要包括 EBV-SMT。
