Department of Behavioral Sciences, Faculty of Medicine, University of Pécs, Szigeti u. 12., Pécs 7624, Hungary.
Epilepsy Behav. 2012 Sep;25(1):110-9. doi: 10.1016/j.yebeh.2012.06.007. Epub 2012 Jul 15.
Calbindin expression of granule cells of the dentate gyrus is decreased in temporal lobe epilepsy (TLE) regardless of its etiology. In this study, we examined the relation between reduction of calbindin immunoreactivity and the verbal and visuo-spatial memory function of patients with TLE of different etiologies. Significant linear correlation was shown between calbindin expression and short-term and long-term percent retention and retroactive interference in auditory verbal learning test (AVLT) of patients including those with hippocampal sclerosis. In addition, we found significant linear regression between calbindin expression and short-term and long-term percent retention of AVLT in patients whose epilepsy was caused by malformation of cortical development or tumor and when no hippocampal sclerosis and substantial neuronal loss were detected. Together with the role of calbindin in memory established in previous studies on calbindin knock-out mice, our results suggest that reduction of calbindin expression may contribute to memory impairments of patients with TLE, particularly, when neuronal loss is not significant.
颗粒细胞层的钙结合蛋白在颞叶癫痫（TLE）中表达减少，而与病因无关。在这项研究中，我们研究了 TLE 患者钙结合蛋白免疫反应性降低与不同病因患者的言语和视觉空间记忆功能之间的关系。在包括海马硬化患者在内的患者的听觉言语学习测试（AVLT）中，钙结合蛋白表达与短期和长期百分比保留和逆行干扰呈显著线性相关。此外，我们还发现，在皮质发育畸形或肿瘤引起的癫痫患者中，当未发现海马硬化和大量神经元丢失时，钙结合蛋白表达与 AVLT 的短期和长期百分比保留之间存在显著线性回归。结合钙结合蛋白在钙结合蛋白敲除小鼠的先前研究中对记忆的作用，我们的结果表明，钙结合蛋白表达的减少可能导致 TLE 患者的记忆障碍，尤其是在神经元丢失不明显时。
