Faculdade Ciências Farmacêuticas, UNESP, Araraquara, Sao Paulo, Brazil.
Colloids Surf B Biointerfaces. 2013 Jan 1;101:156-61. doi: 10.1016/j.colsurfb.2012.06.009. Epub 2012 Jun 29.
The objectives of this work were to study the suitability and highlight the advantages of the use of cross-linked ureasil-polyether hybrid matrices as film-forming systems. The results revealed that ureasil-polyethers are excellent film-forming systems due to specific properties, such as their biocompatibility, their cosmetic attractiveness for being able to form thin and transparent films, their short drying time to form films and their excellent bioadhesion compared to the commercial products known as strong adhesives. Rheological measurements have demonstrated the ability of these hybrid matrices to form a film in only a few seconds and Water Vapor Transmitting Rate (WVTR) showed adequate semi-occlusive properties suggesting that these films could be used as skin and wound protectors. Both the high skin bioadhesion and non-cytotoxic character seems to be improved by the presence of multiple amine groups in the hybrid molecules.
本工作旨在研究交联脲烷-聚醚杂化基质作为成膜系统的适用性,并突出其优势。结果表明,脲烷-聚醚是出色的成膜系统,这归因于其特殊性质,如生物相容性、形成薄而透明薄膜的美感、形成薄膜的干燥时间短以及与商业产品(如强力胶)相比具有出色的生物黏附性。流变学测量证明了这些杂化基质能够在短短几秒钟内形成薄膜,水蒸气透过率 (WVTR) 表明具有足够的半封闭性能,表明这些薄膜可用作皮肤和伤口保护器。高皮肤生物黏附性和非细胞毒性特征似乎都因杂化分子中存在多个胺基而得到改善。