Paplos K, Havaki-Kontaxaki B, Ferentinos P, Dasopoulou M, Kontaxakis V
Department of Psychiatry, "Sotiria" General Hospital, Athens.
Psychiatriki. 2012 Apr-Jun;23(2):149-52.
Over the last decade several studies have discussed the association between serum cholesterol, depressive disorders and suicide. A specific psychological variable related to affect is alexithymia. Alexithymia has been linked to depression and suicidal behaviour. Concerning lipid levels there are several studies that suggest changes in serum lipid composition maybe related to depression and suicidal behaviour. In this study we examined the possible relationship between alexithymia, depression and serum lipids in suicide attempters. We studied 50 non-violent suicide attempters (drug overdosers) with a mean age of 35.0 (±12.2) years. Alexithymia was measured using the Shalling-Sifneos Personality Scale Revised (SSPS-R) and depression using the Montgomery-Asberg Depression Rating Scale (MADRS). Serum lipids concentrations were determined by enzymatic method within 24h of hospital admission. For the statistical evaluation Spearman's rank correlation coefficients were used. The mean serum lipid levels were: total serum cholesterol (TC) 175.2 (±29.6) mg/dL, highdensity lipoprotein cholesterol (H-DLC) 47.08 (±13.1) mg/dL, low density lipoprotein cholesterol (L-DLC) 109.5 (±23.5) mg/dL and the mean serum triglycerides (TR) level was 89.4 (±39.1) mg/dL. The mean scores on the questionnaires were: SSPS-R 10.3 (±3.7), MADRS 33.5 (±5.9). There were significant correlations between: (a) SSPS-R score and MADRS score (r=0.439, p<0.001), (b) SSPS-R score and TR level (r=0.323, p<0.05). There were no significant correlations between MADRS score and any of the lipid fractions measured. To our knowledge, only few studies have examined the association between alexithymia and clinical-psychopathological parameters in suicide attempters. There are no previous studies comparing serum lipid profile with alexithymia in suicide attempters. This is the first study to compare at the same time serum lipids, alexithymia and depression in suicide attempters. The results suggest that although there was a strong relationship between alexithymia and depression in suicide attempters only alexithymia was correlated to Serum triglyceride levels.
在过去十年中，多项研究探讨了血清胆固醇、抑郁症与自杀之间的关联。一种与情感相关的特定心理变量是述情障碍。述情障碍与抑郁症及自杀行为有关。关于血脂水平，有多项研究表明血清脂质成分的变化可能与抑郁症及自杀行为有关。在本研究中，我们调查了自杀未遂者中述情障碍、抑郁症与血清脂质之间可能存在的关系。我们研究了50名非暴力自杀未遂者（药物过量服用者），平均年龄为35.0（±12.2）岁。使用修订后的沙林-西夫neos人格量表（SSPS-R）测量述情障碍，使用蒙哥马利-阿斯伯格抑郁评定量表（MADRS）测量抑郁症。在入院后24小时内通过酶法测定血清脂质浓度。统计评估采用Spearman等级相关系数。平均血清脂质水平为：总血清胆固醇（TC）175.2（±29.6）mg/dL，高密度脂蛋白胆固醇（H-DLC）47.08（±13.1）mg/dL，低密度脂蛋白胆固醇（L-DLC）109.5（±23.5）mg/dL，平均血清甘油三酯（TR）水平为89.4（±39.1）mg/dL。问卷的平均得分分别为：SSPS-R 10.3（±3.7），MADRS 33.5（±5.9）。存在显著相关性：（a）SSPS-R得分与MADRS得分（r = 0.439，p < 0.001），（b）SSPS-R得分与TR水平（r = 0.323，p < 0.05）。MADRS得分与所测量的任何脂质成分之间均无显著相关性。据我们所知，仅有少数研究调查了自杀未遂者中述情障碍与临床心理病理参数之间的关联。此前没有研究比较自杀未遂者的血清脂质谱与述情障碍。这是第一项同时比较自杀未遂者的血清脂质、述情障碍和抑郁症的研究。结果表明，虽然自杀未遂者中述情障碍与抑郁症之间存在密切关系，但只有述情障碍与血清甘油三酯水平相关。
