Engström G, Alsén M, Regnéll G, Träskman-Bendz L
Lund Suicide Research Center, Department of Psychiatry, University Hospital, Sweden.
Suicide Life Threat Behav. 1995 Fall;25(3):393-400.
As other studies have shown possible associations of low serum cholesterol concentrations as well as serotonin and corticosteroid deviances with suicide or depression, the present study was undertaken to investigate the serum lipid levels in subgroups of suicide attempters. Serum lipids were determined in 72 suicide attempters. Cerebrospinal fluid monoamine metabolites and plasma cortisol levels were measured, and dexamethasone suppression tests were performed. Hopelessness and suicidality were rated by the Hopelessness Scale (HS) and the Suicidal Intent Scales (SIS). The mean total serum cholesterol (TSC) level was 5.0 +/- 1.2 mmol/L. We found no significant correlations between TSC and the monoamine metabolites. High-density lipoprotein cholesterol showed positive correlations with the dopamine metabolite homovanillic acid (r = 0.39, p = 0.04) and the serotonin metabolite 5-hydroxyindoleacetic acid (r = 0.34, p = 0.07). The SIS and HS scales did not correlate significantly with serum lipids. "Violent" attempters showed somewhat higher serum lipid levels than "nonviolent" attempters. We found no significant differences in serum lipid levels between the diagnostic subgroups. Hence, we could not find much support for the hypothesis of associations between low cholesterol levels and decreased serotonin activity in the brain. However, this field merits further investigation.
正如其他研究表明血清胆固醇浓度低以及血清素和皮质类固醇异常与自杀或抑郁之间可能存在关联一样，本研究旨在调查自杀未遂者亚组中的血脂水平。对72名自杀未遂者测定了血脂。测量了脑脊液单胺代谢物和血浆皮质醇水平，并进行了地塞米松抑制试验。绝望感和自杀倾向通过绝望量表（HS）和自杀意图量表（SIS）进行评估。血清总胆固醇（TSC）平均水平为5.0±1.2mmol/L。我们发现TSC与单胺代谢物之间无显著相关性。高密度脂蛋白胆固醇与多巴胺代谢物高香草酸呈正相关（r = 0.39，p = 0.04），与血清素代谢物5-羟吲哚乙酸呈正相关（r = 0.34，p = 0.07）。SIS和HS量表与血脂无显著相关性。“暴力”未遂者的血脂水平略高于“非暴力”未遂者。我们发现诊断亚组之间的血脂水平无显著差异。因此，我们没有找到太多证据支持低胆固醇水平与大脑血清素活性降低之间存在关联的假设。然而，这一领域值得进一步研究。
