RIBFIND：一个用于识别蛋白质结构中刚体的网络服务器，并辅助刚体在低温电子显微镜映射中的灵活拟合。
RIBFIND: a web server for identifying rigid bodies in protein structures and to aid flexible fitting into cryo EM maps.
机构信息
Department of Crystallography/Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, UK.
出版信息
Bioinformatics. 2012 Sep 15;28(18):2391-3. doi: 10.1093/bioinformatics/bts446. Epub 2012 Jul 12.
MOTIVATION
To better analyze low-resolution cryo electron microscopy maps of macromolecular assemblies, component atomic structures frequently have to be flexibly fitted into them. Reaching an optimal fit and preventing the fitting process from getting trapped in local minima can be significantly improved by identifying appropriate rigid bodies (RBs) in the fitted component.
RESULTS
Here we present the RIBFIND server, a tool for identifying RBs in protein structures. The server identifies RBs in proteins by calculating spatial proximity between their secondary structural elements.
AVAILABILITY
The RIBFIND web server and its standalone program are available at http://ribfind.ismb.lon.ac.uk.
CONTACT
a.pandurangan@mail.cryst.bbk.ac.uk
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
动机
为了更好地分析大分子组装体的低分辨率冷冻电子显微镜图谱，通常需要将组成原子结构灵活地拟合到图谱中。通过在拟合的组件中识别适当的刚体 (RB)，可以显著提高达到最佳拟合和防止拟合过程陷入局部最小值的能力。
结果
本文介绍了 RIBFIND 服务器，这是一种用于识别蛋白质结构中 RB 的工具。该服务器通过计算其二级结构元素之间的空间接近度来识别蛋白质中的 RB。
可用性
RIBFIND 网络服务器及其独立程序可在 http://ribfind.ismb.lon.ac.uk 获得。
联系方式
a.pandurangan@mail.cryst.bbk.ac.uk
补充信息
补充数据可在“Bioinformatics”在线获取。
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