进展性非流利型失语症、失语法性进行性失语症和阿尔茨海默病患者的日常生活活动。
Activities of daily living in progressive non-fluent aphasia, logopenic progressive aphasia and Alzheimer's disease.
机构信息
Neuroscience Research Australia, Sydney, Australia.
出版信息
Dement Geriatr Cogn Disord. 2012;33(5):354-60. doi: 10.1159/000339670. Epub 2012 Jul 10.
BACKGROUND/AIMS: This study examined functional changes in progressive non-fluent aphasia (PNFA) and logopenic progressive aphasia (LPA) and Alzheimer's disease (AD) and the association between function, cognition and behaviour.
METHODS
59 patients were assessed with the Disability Assessment of Dementia (DAD), Addenbrooke's Cognitive Examination Revised (ACE-R) and the Cambridge Behavioural Inventory Revised (CBI-R).
RESULTS
No differences between groups in basic and instrumental activities of daily living (ADLs), and total ACE-R scores were found; there were correlations between total DAD and ACE-R scores for PNFA and LPA. Over 12 months, PNFA showed the marked decline of basic ADLs, whereas all three groups showed marked decline of instrumental ADLs.
CONCLUSION
PNFA, LPA and AD appear functionally similar when matched for disease duration. The rate of decline of ADLs depends, however, on disease diagnosis.
背景/目的：本研究考察了进行性非流利性失语症（PNFA）、语义性进行性失语症（LPA）和阿尔茨海默病（AD）的功能变化，以及功能、认知和行为之间的关系。
方法
59 名患者接受了痴呆残疾评估（DAD）、改良 Addenbrooke 认知测验（ACE-R）和剑桥行为量表修订版（CBI-R）的评估。
结果
未发现各组在日常生活基本活动和工具性活动（ADLs）以及 ACE-R 总分方面存在差异；PNFA 和 LPA 患者的 DAD 总分与 ACE-R 评分存在相关性。在 12 个月内，PNFA 患者的基本 ADL 明显下降，而所有三组患者的工具性 ADL 都明显下降。
结论
当匹配疾病持续时间时，PNFA、LPA 和 AD 在功能上似乎相似。然而，ADLs 的下降速度取决于疾病的诊断。
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