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本文引用的文献

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Radiation retinopathy is treatable with anti-vascular endothelial growth factor bevacizumab (Avastin).放射性视网膜病变可用抗血管内皮生长因子贝伐单抗(阿瓦斯汀)进行治疗。
Int J Radiat Oncol Biol Phys. 2008 Mar 15;70(4):974-7. doi: 10.1016/j.ijrobp.2007.11.045.
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Ophthalmic and adnexal complications of radiotherapy.放射治疗的眼部及附属器并发症。
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Radiation retinopathy: case report and review.放射性视网膜病变:病例报告与综述
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Choroidal neovascular membrane in radiation retinopathy.放射性视网膜病变中的脉络膜新生血管膜
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Vascular endothelial growth factor: basic science and clinical progress.血管内皮生长因子:基础科学与临床进展
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Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project.近期诊断的恶性胶质瘤手术后的生存率及预后因素:来自胶质瘤结局项目的数据。
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Atypical choroidal neovascularization in radiation retinopathy.
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Late retinal complications of radiation therapy for nasal and paranasal malignancies: relationship between irradiated-dose area and severity.鼻腔和鼻窦恶性肿瘤放射治疗的晚期视网膜并发症:照射剂量区域与严重程度之间的关系。
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脑部放疗后迟发性黄斑中心凹下脉络膜新生血管形成

Late onset of subfoveal choroidal neovascularisation following cerebral radiotherapy.

作者信息

Ghauri Abdul-Jabbar, Musadiq Mohammed, Sha Ying, Elsherbiny Samer

机构信息

Department of Ophthalmology, Birmingham and Midlands Eye Centre, Birmingham, UK.

出版信息

BMJ Case Rep. 2010 Nov 23;2010:bcr0520091825. doi: 10.1136/bcr.05.2009.1825.

DOI:10.1136/bcr.05.2009.1825
PMID:22797201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3027866/
Abstract

A report of choroidal neovascularisation (CNV) associated with radiation retinopathy. A 43-year-old Caucasian man presented with a 4-week history of sudden loss of central vision in the left eye, 8.5 years following radical radiotherapy for left tempero-parietal anaplastic astrocytoma. His visual acuity was 6/6 in the right eye and 6/60 in the left eye. Ophthalmoscopy of the left eye showed central macular pigmented area surrounded by subretinal fluid, haemorrhage and exudates. Fundus fluorescein angiography revealed left subfoveal CNV with surrounding macular oedema and peripheral retinal ischaemia. Radiation retinopathy associated CNV is a late ocular complication of cerebral radiotherapy. It should be investigated as a possible aetiology of severe visual loss in long-term survivors of cerebral tumours who have previously received radiotherapy.

摘要

一份关于放射性视网膜病变相关脉络膜新生血管形成(CNV)的报告。一名43岁的白种男性,在接受左侧颞顶间变性星形细胞瘤根治性放疗8.5年后,出现左眼中心视力突然丧失4周的症状。他的右眼视力为6/6,左眼视力为6/60。左眼检眼镜检查显示中心黄斑色素沉着区被视网膜下液、出血和渗出物包围。眼底荧光血管造影显示左黄斑下CNV伴周围黄斑水肿和周边视网膜缺血。放射性视网膜病变相关的CNV是脑部放疗的一种晚期眼部并发症。对于先前接受过放疗的脑肿瘤长期幸存者中严重视力丧失的可能病因,应将其作为一种可能病因进行调查。