Durkin Shane R, Roos Daniel, Higgs Braden, Casson Robert J, Selva Dinesh
Department of Ophthalmology and Visual Sciences, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Acta Ophthalmol Scand. 2007 May;85(3):240-50. doi: 10.1111/j.1600-0420.2006.00822.x.
The role of radiotherapy in ophthalmic practice continues to grow. This growth has seen an expansion of indications for radiotherapy, a refinement of the modalities that can be used and a reduction in the ocular and adnexal complications that result from this form of therapy. The compendium of indications for radiotherapy in ophthalmology continues to grow and now includes many conditions such as the treatment of lid and adnexal disease, ocular surface disorders and both benign and malignant disease of the posterior segment and optic pathways. The radiotherapeutic modalities employed to manage these conditions are numerous and include both radioactive plaques (brachytherapy) and external beam radiation techniques. New techniques such as stereotactic radiosurgery are delivering benefits in the management of conditions such as optic nerve sheath meningioma, where the treatment of this blinding and occasionally life-threatening intracranial neoplasm now results in fewer adverse affects. The purpose of this review is to give a brief overview of the indications and treatment modalities, and a more in-depth discussion of the potential side-effects when radiotherapy is used for ocular and periorbital disease.
放射治疗在眼科实践中的作用持续增强。这种发展体现在放射治疗适应证的扩展、可采用的治疗方式的优化以及这种治疗形式所导致的眼部和附属器并发症的减少。眼科放射治疗的适应证汇编持续增加，目前包括许多病症，如眼睑和附属器疾病的治疗、眼表疾病以及眼后段和视路的良性和恶性疾病。用于治疗这些病症的放射治疗方式多种多样，包括放射性敷贴（近距离放射治疗）和外照射技术。立体定向放射外科等新技术在视神经鞘膜瘤等病症的治疗中带来了益处，对于这种致盲且偶尔危及生命的颅内肿瘤的治疗，现在产生的不良影响较少。本综述的目的是简要概述适应证和治疗方式，并更深入地讨论放射治疗用于眼部和眶周疾病时可能出现的副作用。
