Department of Dermatology, VA Northern California Health Care Systems, and the University of California, Davis, California 95616, USA.
J Invest Dermatol. 2012 Aug;132(8):1955-8. doi: 10.1038/jid.2012.208.
Toll-like receptors (TLRs) are considered to be the first responders in the defense against invading pathogens. TLR engagement by ligands triggers inflammatory responses in injury and trauma, and thus can impair or contribute to the healing process, depending on TLRs' expression pattern, cellular localization, signaling, and deployment of inflammatory responses. Understanding these attributes could improve therapeutic strategies for treating chronic wounds.
Toll 样受体（TLRs）被认为是抵御入侵病原体的第一道防线。配体与 TLR 的结合可引发损伤和创伤中的炎症反应，因此，TLRs 的表达模式、细胞定位、信号转导以及炎症反应的发生情况决定了其对愈合过程是有害还是有益。了解这些特性可以改善治疗慢性伤口的治疗策略。
