通过三色流式细胞术在由CD4和CD8定义的所有胸腺细胞亚群中检测到CD45RA。
CD45RA is detected in all thymocyte subsets defined by CD4 and CD8 by using three-colour flow cytometry.
作者信息
Lightstone E B, Marvel J
机构信息
ICRF Tumour Immunology Unit, University College London.
出版信息
Immunology. 1990 Dec;71(4):467-72.
Abstract
In the mouse, using three-colour flow cytometry, the presence of CD45RA+ cells is demonstrated amongst all of the thymocyte subsets defined by expression of CD4 and CD8, i.e. amongst the double negatives, immature CD8 single positives, double-positive blasts and CD4 and CD8 single positives. This evidence is compatible with the existence of a continuous lineage of T cells expressing CD45RA which would develop from double-negative to mature single-positive T cells.
摘要
在小鼠中，利用三色流式细胞术，在所有由CD4和CD8表达所定义的胸腺细胞亚群中，即双阴性、未成熟CD8单阳性、双阳性母细胞以及CD4和CD8单阳性细胞中，均证实了CD45RA+细胞的存在。这一证据与存在一个表达CD45RA的连续T细胞谱系相符，该谱系将从双阴性T细胞发育为成熟的单阳性T细胞。
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