Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China.
Neurol Sci. 2013 Jan;34(1):11-7. doi: 10.1007/s10072-012-1145-3. Epub 2012 Jul 15.
Spinal cord injury (SCI) is induced by a variety of damages such as trauma, ischemia, and iatrogenic injury, resulting in sense and motion dysfunction. Despite the improvements in medical and surgical care, current treatment methods for SCI demonstrate poor and delayed efficiency, leading to different degree of permanent loss of neural function and disability in the patients. Rapid advances in stem-cells research suggest that stem cells may be applied in SCI therapy. Indeed, SCI is a major field in which stem-cell therapy has been proposed and practised, and most recently the clinical trials of stem-cell therapy were initiated, which aroused a number of clinical concerns. In this review, we summarize current status of SCI repair, then introduce the sources and biological characteristics of induced pluripotent stem cells (iPSCs), and discuss the differentiation potential of iPSCs and the perspective of the application of iPSCs in SCI therapy.
脊髓损伤（SCI）是由多种损伤引起的，如创伤、缺血和医源性损伤，导致感觉和运动功能障碍。尽管在医疗和手术方面有所改进，但目前 SCI 的治疗方法效果不佳且延迟，导致患者不同程度的永久性神经功能丧失和残疾。干细胞研究的快速进展表明，干细胞可能应用于 SCI 治疗。事实上，SCI 是干细胞治疗提出和实践的主要领域，最近已经开始进行干细胞治疗的临床试验，这引起了许多临床关注。在这篇综述中，我们总结了 SCI 修复的现状，然后介绍了诱导多能干细胞（iPSCs）的来源和生物学特性，并讨论了 iPSCs 的分化潜能和在 SCI 治疗中的应用前景。
