Pal R, Katiyar J C
Division of Parasitology, Central Drug Research Institute, Lucknow, India.
Indian J Exp Biol. 1990 Sep;28(9):876-9.
Susceptibility of animals to infections depends upon various factors including sex of the host which plays a pivotal role. The intake of L. donovani was investigated in male and female hamsters as also in gonadectomized and hormone (sex) treated animals. Male hamsters developed more parasites (55/100 cell nuclei) than their female counterparts (22/100 cell nuclei). The hamsters receiving testosterone (250 micrograms/animal for 7 days) exogenously (im) had enhanced parasitic count (1.1-fold in male and 1.5-fold in females with respect to their respective controls). Administration of estradiol (3 micrograms/animal for 3 days) suppressed the infection in males by 2.5-fold and in female by 1.94-fold. Castration lowered the parasite 'in take' while ovarectomy promoted infection. In these (gonadectomized) animals the administration of testosterone in males restored parasite load while the estradiol therapy in females suppressed the infection. The results suggest a definite modulatory role of sex hormone, in the susceptibility of hamsters to L. donovani infection.
动物对感染的易感性取决于多种因素，包括宿主性别，而宿主性别起着关键作用。研究了雄性和雌性仓鼠以及去势和接受激素（性激素）处理的动物对杜氏利什曼原虫的摄取情况。雄性仓鼠体内的寄生虫数量（55/100个细胞核）比雌性仓鼠（22/100个细胞核）更多。通过肌肉注射外源给予睾酮（250微克/只，持续7天）的仓鼠，其寄生虫数量增加（雄性相对于各自对照组增加1.1倍，雌性增加1.5倍）。给予雌二醇（3微克/只，持续3天）使雄性感染率降低2.5倍，雌性降低1.94倍。去势降低了寄生虫“摄取量”，而卵巢切除则促进了感染。在这些（去势）动物中，雄性给予睾酮可恢复寄生虫负荷，而雌性给予雌二醇治疗则可抑制感染。结果表明性激素对仓鼠感染杜氏利什曼原虫的易感性具有明确的调节作用。
