Department of Laboratory, Affiliated Houjie Hospital, Guangdong Medical College, 523945, Dongguan, China.
Endocrine. 2013 Apr;43(2):346-50. doi: 10.1007/s12020-012-9741-9. Epub 2012 Jul 14.
The aim of this study was to assess the relationship between urinary Smad1 and glomerular hyperfiltration (GHF) in type 2 diabetes mellitus (T2DM), and to explore the factors related to the urinary Smad1 in T2DM. The reference value of the estimated glomerular filtration rate (eGFR) was determined in 248 healthy individuals. 30 patients with GHF, 58 patients with norm-GFR T2DM, and 24 healthy patients who served as controls were recruited. Urinary Smad1, fasting plasma glucose (FPG), fasting serum C-Peptide (C-P), hemoglobin A1C (HbA1c), cystatin C, and other chemistry laboratory parameters of T2DM participants and controls were measured. Patients with GHF had higher levels of urinary Smad1 than the control group, and those with norm-GFR. For T2DM patients with body mass index, age, and gender adjustments, urinary Smad1 was positively correlated with FPG, HbA1C, and eGFR, but negatively correlated with fasting serum C-P. Multivariate linear regression analysis demonstrated that eGFR, HbA1C, and fasting serum C-P were independently associated with urinary Smad1. High levels of urinary Smad1 were found in GHF patients with T2DM, which may be another potential mechanism of GHF in relation to diabetic nephropathy.
本研究旨在评估 2 型糖尿病（T2DM）患者尿液 Smad1 与肾小球高滤过（GHF）之间的关系，并探讨 T2DM 患者尿液 Smad1 相关的因素。在 248 名健康个体中确定了估算肾小球滤过率（eGFR）的参考值。招募了 30 名 GHF 患者、58 名 norm-GFR T2DM 患者和 24 名健康对照者。测量了 T2DM 患者和对照组的尿液 Smad1、空腹血糖（FPG）、空腹血清 C-肽（C-P）、糖化血红蛋白（HbA1c）、胱抑素 C 和其他化学实验室参数。GHF 患者的尿液 Smad1 水平高于对照组和 norm-GFR 患者。对 T2DM 患者的体重指数、年龄和性别进行调整后，尿液 Smad1 与 FPG、HbA1c 和 eGFR 呈正相关，与空腹血清 C-P 呈负相关。多元线性回归分析表明，eGFR、HbA1c 和空腹血清 C-P 与尿液 Smad1 独立相关。在患有 T2DM 的 GHF 患者中发现了高水平的尿液 Smad1，这可能是 GHF 与糖尿病肾病相关的另一个潜在机制。
