Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA.
Pharm Res. 2013 Jan;30(1):25-31. doi: 10.1007/s11095-012-0825-2. Epub 2012 Jul 14.
To explore surface-immobilized and suspended modalities of the hydrophobic polycation N,N-dodecyl,methyl-polyethylenimine (DMPEI) for the ability to reduce viral infectivity in aqueous solutions containing herpes simplex viruses (HSVs) 1 and 2.
Surface-immobilized (coated onto surfaces) and suspended DMPEI were incubated with aqueous solutions containing HSV-1 or -2 to measure the antiviral effect of the hydrophobic polycation's formulations on HSVs.
DMPEI coated on either polyethylene slides or male latex condoms dramatically decreases infectivity in solutions containing HSV-1 or -2. Moreover, DMPEI suspended in aqueous solution markedly reduces the infectious titer of these HSVs.
Our results suggest potential uses of DMPEI for both prophylaxis (in the form of coated condoms) and treatment (as a topical suspension) for HSV infections.
探索疏水性聚阳离子 N,N-十二烷基，甲基-聚亚乙基亚胺（DMPEI）的表面固定化和悬浮两种方式，以研究其在含有单纯疱疹病毒（HSV）1 和 2 的水溶液中降低病毒感染力的能力。
将表面固定化（涂覆在表面上）和悬浮的 DMPEI 与含有 HSV-1 或 -2 的水溶液孵育，以测量疏水性聚阳离子制剂对 HSV 的抗病毒效果。
涂覆在聚乙烯片或男用乳胶安全套上的 DMPEI 可显著降低含有 HSV-1 或 -2 的溶液中的感染力。此外，悬浮在水溶液中的 DMPEI 明显降低了这些 HSV 的感染滴度。
我们的结果表明，DMPEI 可能有两种用途，即作为预防性措施（以涂层安全套的形式）和治疗性措施（作为局部混悬剂），用于 HSV 感染。
