Jiang X, Li Z, Young D J, Liu M, Wu C, Wu Y-L, Loh X J
Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.
Institute of Materials Research and Engineering, A∗STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore.
Mater Today Adv. 2021 Jun;10:100140. doi: 10.1016/j.mtadv.2021.100140. Epub 2021 Mar 20.
Severe acute respiratory syndrome-associated coronavirus 2 has caused a global public health crisis with high rates of infection and mortality. Treatment and prevention approaches include vaccine development, the design of small-molecule antiviral drugs, and macromolecular neutralizing antibodies. Polymers have been designed for effective virus inhibition and as antiviral drug delivery carriers. This review summarizes recent progress and provides a perspective on polymer-based approaches for the treatment and prevention of coronavirus infection. These polymer-based partners include polyanion/polycations, dendritic polymers, macromolecular prodrugs, and polymeric drug delivery systems that have the potential to significantly improve the efficacy of antiviral therapeutics.
严重急性呼吸综合征冠状病毒2引发了一场全球公共卫生危机，感染率和死亡率都很高。治疗和预防方法包括疫苗研发、小分子抗病毒药物设计以及大分子中和抗体。聚合物已被设计用于有效抑制病毒，并作为抗病毒药物的递送载体。本综述总结了近期的进展，并对基于聚合物的冠状病毒感染治疗和预防方法提供了一个视角。这些基于聚合物的组合包括聚阴离子/聚阳离子、树枝状聚合物、大分子前药以及聚合物药物递送系统，它们有可能显著提高抗病毒治疗的疗效。
