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Diffuse idiopathic neuroendocrine cell hyperplasia: an unusual cause of breathlessness and pulmonary nodules.弥漫性特发性神经内分泌细胞增生症:导致呼吸困难和肺结节的罕见病因。
BMJ Case Rep. 2010 Dec 1;2010:bcr0520103006. doi: 10.1136/bcr.05.2010.3006.
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A 75-Year-Old Woman With Pulmonary Nodules and Dyspnea.一位 75 岁女性,肺部结节,呼吸困难。
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Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: A Case With Long-term Follow-up.弥漫性特发性肺神经内分泌细胞增生症:一例长期随访病例
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Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: An Asthma Mimicker.弥漫性特发性肺神经内分泌细胞增生症:一种类似哮喘的病症。
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Rare diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: one case report and literature review.罕见的弥漫性特发性肺神经内分泌细胞增生症:一例报告并文献复习
Transl Cancer Res. 2020 Dec;9(12):7657-7661. doi: 10.21037/tcr-20-1783.
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Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence.弥漫性特发性肺神经内分泌细胞增生症(DIPNECH):当前最佳证据
Lung. 2015 Oct;193(5):659-67. doi: 10.1007/s00408-015-9755-1. Epub 2015 Jun 24.
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DIPNECH presenting on a background of malignant melanoma: new lung nodules are not always what they seem.以恶性黑色素瘤为背景出现的弥漫性特发性肺神经内分泌细胞增生症:新出现的肺结节并不总是如其所见。
BMJ Case Rep. 2014 Feb 26;2014:bcr2014203667. doi: 10.1136/bcr-2014-203667.

本文引用的文献

1
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia accompanied by airflow obstruction.弥漫性特发性肺神经内分泌细胞增生伴气流阻塞。
J Bras Pneumol. 2009 May;35(5):489-94. doi: 10.1590/s1806-37132009000500017.
2
[Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a rare preneoplastic condition].[弥漫性特发性肺神经内分泌细胞增生症:一种罕见的肿瘤前状态]
Rev Mal Respir. 2008 Nov;25(9):1131-5. doi: 10.1016/s0761-8425(08)74985-4.
3
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) in association with an adenocarcinoma: a case report.弥漫性特发性肺神经内分泌细胞增生症(DIPNECH)合并腺癌:一例报告
J Med Case Rep. 2008 Jan 25;2:21. doi: 10.1186/1752-1947-2-21.
4
Neuroendocrine cell hyperplasia as an unusual form of interstitial lung disease.神经内分泌细胞增生作为间质性肺疾病的一种罕见形式。
Respir Med. 2007 Aug;101(8):1840-3. doi: 10.1016/j.rmed.2005.10.024.
5
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease.弥漫性特发性肺神经内分泌细胞增生症:一种未被充分认识的疾病谱。
Thorax. 2007 Mar;62(3):248-52. doi: 10.1136/thx.2006.063065. Epub 2006 Nov 10.
6
[EGFR-expression in pulmonary neuroendocrine cell hyperplasia].[肺神经内分泌细胞增生中的表皮生长因子受体表达]
Pathologe. 2006 Mar;27(2):147-51. doi: 10.1007/s00292-006-0819-0.
7
Preneoplastic lesions of the lung.肺的癌前病变
Respir Res. 2002;3(1):20. doi: 10.1186/rr170. Epub 2002 Apr 4.
8
Diffuse idiopathic pulmonary neuroendocrine cell proliferation presenting as interstitial lung disease.表现为间质性肺疾病的弥漫性特发性肺神经内分泌细胞增生
Am J Surg Pathol. 1995 Aug;19(8):963-70. doi: 10.1097/00000478-199508000-00013.
9
Pulmonary endocrine cells in chronic bronchitis and emphysema.慢性支气管炎和肺气肿中的肺内分泌细胞。
J Pathol. 1989 Feb;157(2):127-33. doi: 10.1002/path.1711570207.

弥漫性特发性神经内分泌细胞增生症:导致呼吸困难和肺结节的罕见病因。

Diffuse idiopathic neuroendocrine cell hyperplasia: an unusual cause of breathlessness and pulmonary nodules.

作者信息

Tippett V M, Wathen C G

机构信息

Department of Respiratory Medicine, Wycombe Hospital, High Wycombe, UK.

出版信息

BMJ Case Rep. 2010 Dec 1;2010:bcr0520103006. doi: 10.1136/bcr.05.2010.3006.

DOI:10.1136/bcr.05.2010.3006
PMID:22798306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3029669/
Abstract

A 66-year-old woman presented with dry cough and subsequent intermittent breathlessness and wheeze. During this time she was treated by her general practitioner for chronic obstructive pulmonary disease. When her symptoms worsened and her lung function had deteriorated, a high resolution CT scan was undertaken. This showed bilateral fine nodules. Investigations did not support a diagnosis of vasculitis and sarcoidosis was suspected. A lung biopsy was performed that showed diffuse idiopathic neuroendocrine cell hyperplasia. At follow-up, to date, the patient remains symptomatic but has not progressed or developed a carcinoid tumour.

摘要

一名66岁女性出现干咳,随后间歇性呼吸急促和喘息。在此期间,她的全科医生对其进行了慢性阻塞性肺疾病的治疗。当她的症状恶化且肺功能下降时,进行了高分辨率CT扫描。扫描显示双侧有小结节。检查结果不支持血管炎的诊断,怀疑为结节病。进行了肺活检,结果显示为弥漫性特发性神经内分泌细胞增生。截至随访时,患者仍有症状,但病情未进展,也未发展为类癌肿瘤。