Gosney J R, Sissons M C, Allibone R O, Blakey A F
Department of Pathology, University of Liverpool, U.K.
J Pathol. 1989 Feb;157(2):127-33. doi: 10.1002/path.1711570207.
Pulmonary endocrine cells have been studied according to their immunoreactivity for neuron-specific enolase, gastrin-releasing peptide (GRP), calcitonin, leucine-enkephalin, and serotonin in the lungs of subjects with chronic bronchitis and emphysema. The overall population was significantly greater in comparison with matched controls. The change was most marked in lobes affected by pneumonic consolidation, and did not affect equally the sub-populations of cells as identified by their content of peptide; the difference was much greater for calcitonin-containing cells than for those immunoreactive for GRP. This change may be the basis of the hypercalcitoninaemia and hypercalcitoninuria which have been reported in patients with inflammatory pulmonary disease.
根据慢性支气管炎和肺气肿患者肺部的神经元特异性烯醇化酶、胃泌素释放肽（GRP）、降钙素、亮氨酸脑啡肽和5-羟色胺的免疫反应性，对肺内分泌细胞进行了研究。与匹配的对照组相比，总体数量显著增加。这种变化在受肺炎实变影响的肺叶中最为明显，并且对根据肽含量确定的细胞亚群的影响并不相同；含降钙素的细胞与对GRP免疫反应的细胞相比，差异要大得多。这种变化可能是炎症性肺病患者中报道的高降钙素血症和高降钙素尿症的基础。
