从柬埔寨龙血树中分离得到的三种新双黄酮类化合物。

Three new biflavonoids from Chinese dragon's blood, Dracaena cochinchinensis.

作者信息

Guan Jing, Guo Shun-Xing

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China.

出版信息

Nat Prod Commun. 2012 May;7(5):591-4.

PMID:22799082

Abstract

Three new biflavonoids, named (2RyS)-3'-methoxy-8-methylsocotrin-4'-ol (1), (2SyR)-3'-methoxy-8-methylsocotrin-4'-ol (2), and (2RyR)-8-methylsocotrin-4'-ol (3), were isolated from Chinese Dragon's blood [Dracaena cochinchinensis (Lour.) S. C. Chen], together with two known ones. The structures of these new biflavonoids were elucidated by a combination of HR-ESI-MS, 1H NMR, 13C NMR, HMQC, and HMBC spectra. The absolute configurations of compounds 1-4 were determined by quantum chemical calculation of the circular dichroism spectrum and comparison with the experimental CD spectrum.

摘要

从国产血竭[柬埔寨龙血树（Lour.）S. C. Chen]中分离出三种新的双黄酮类化合物，分别命名为(2RyS)-3'-甲氧基-8-甲基索科特拉因-4'-醇（1）、(2SyR)-3'-甲氧基-8-甲基索科特拉因-4'-醇（2）和(2RyR)-8-甲基索科特拉因-4'-醇（3），同时还分离出两种已知化合物。通过高分辨电喷雾电离质谱（HR-ESI-MS）、1H核磁共振（1H NMR）、13C核磁共振（13C NMR）、异核多量子相干谱（HMQC）和异核多键相关谱（HMBC）等多种光谱技术相结合的方法阐明了这些新双黄酮类化合物的结构。通过对圆二色光谱进行量子化学计算并与实验圆二色光谱进行比较，确定了化合物1-4的绝对构型。