Liu Ai-Jun, Zong Hong, Yang Guang-Zhong, Zhai Yu-Hua, Li Li-Hong
Department of Hematology, Chao Yang Hospital, Capital Medical University, Beijing, China.
Asian Pac J Cancer Prev. 2012;13(4):1483-6. doi: 10.7314/apjcp.2012.13.4.1483.
To determine the characteristics of oligoclonal bands that are frequently detected by serum protein electrophoresis (SPEP) and immunofixation electrophoresis (IFE) after stem cell transplantation.
We retrospectively analyzed 56 patients with multiple myeloma (MM) undergoing transplantation, and standard immunofixation electrophoresis was used to identify and quantify paraproteins.
The median follow-up was 35 months (range, 10-76 months) and 21 patients relapsed. Twelve (25.0%) demonstrated oligoclonal bands after a median time 1.4 months (range, 1-3 months), with a median duration of 5.8 months (range, 1-15 months). The majority patients with oligoclonal bands had normal quantities of immunoglobulins and the one year event free survival (EFS) was 92%, even higher than for patients without OBs (P=0.002).
Oligoclonal bands frequent develop post-transplantation in MM cases. In the vast majority of patients, they may not represent relapsed disease, and more likely represent a transient phenomenon representing recovery of impaired immunoglobulin production.
确定干细胞移植后血清蛋白电泳（SPEP）和免疫固定电泳（IFE）频繁检测到的寡克隆带的特征。
我们回顾性分析了56例接受移植的多发性骨髓瘤（MM）患者，并使用标准免疫固定电泳来鉴定和定量副蛋白。
中位随访时间为35个月（范围10 - 76个月），21例患者复发。12例（25.0%）在中位时间1.4个月（范围1 - 3个月）后出现寡克隆带，中位持续时间为5.8个月（范围1 - 15个月）。大多数有寡克隆带的患者免疫球蛋白量正常，一年无事件生存率（EFS）为92%，甚至高于无寡克隆带的患者（P = 0.002）。
MM病例移植后频繁出现寡克隆带。在绝大多数患者中，它们可能不代表疾病复发，更可能代表免疫球蛋白产生受损恢复的一种短暂现象。
