ZHANG Yuan, ZHAO Yan-ming, DUAN Su, ZHAO Li-ping, ZHANG Luo
Key Laboratory of Otorhinolaryngology, Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing Institute of Otorhinolaryngology, Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Apr;47(4):289-93.
To investigate whether the single nucleotide polymorphisms (SNP) in the FCER1A gene are associated with serum total IgE level in Chinese allergic rhinitis (AR) cohort.
A total of 378 patients diagnosed as AR was included in this study. Serum total IgE level was detected by UniCAP100 testing system. A total of 8 representativeness marker SNP which were in FCER1A gene region were selected according to the Beijing people database from Hapmap website and the running results of Haploview 4.1 software. The individual genotyping was performed by MassARRAY platform.
Three hundred and seventy-eight individuals (227 males and 151 females) with AR were prospectively recruited. The median of the total serum IgE measurements for the study population were 150 kU/L and ranged from 6.94 kU/L to 5000 kU/L. Levene tests showed the homogeneity of variance of total IgE level among different genotypes regarding each SNP locus. ANOVA tests demonstrated that none of the selected polymorphism loci in FCER1A was associated with total IgE level.
Present study failed to find an association between SNP in the FCER1A gene region and serum total IgE level in Chinese AR.
探讨中国变应性鼻炎（AR）队列中FCER1A基因单核苷酸多态性（SNP）是否与血清总IgE水平相关。
本研究共纳入378例诊断为AR的患者。采用UniCAP100检测系统检测血清总IgE水平。根据Hapmap网站的北京人群数据库及Haploview 4.1软件的运行结果，在FCER1A基因区域选择8个具有代表性的标记SNP。采用MassARRAY平台进行个体基因分型。
前瞻性招募了378例AR患者（227例男性和151例女性）。研究人群血清总IgE测量值的中位数为150 kU/L，范围为6.94 kU/L至5000 kU/L。Levene检验显示，每个SNP位点不同基因型间总IgE水平的方差具有齐性。方差分析表明，FCER1A中所选的多态性位点均与总IgE水平无关。
本研究未发现中国AR患者FCER1A基因区域SNP与血清总IgE水平之间存在关联。
