Zhu Jia-li, Zheng Qin-xiang, Li Wen-sheng
Eye Hospital, Wenzhou Medical College, Wenzhou 325027, China.
Zhonghua Yan Ke Za Zhi. 2012 Apr;48(4):374-8.
Retinal degeneration diseases are a group of severe eye diseases that can lead to blindness. They are characterized by degeneration and apoptosis of photoreceptor cells and still lacking effective therapeutic procedures. Pluripotent stem cells (induced pluripotent stem cells, iPS cells) obtained from somatic cell reprogramming are similar to the embryonic stem cells (embryonic stem cells, ES cells), which have unlimited proliferation, differentiation and memory characteristics. Retinal cells from iPS cells have been used in cell transplantation for the treatment of retinal diseases, for the study of pathogenesis and drug toxicity evaluation in retinal degenerative diseases. This may provide new ideas and novel procedures for the treatment of retinal degenerative diseases in the future.
视网膜退行性疾病是一组可导致失明的严重眼部疾病。它们的特征是光感受器细胞的退化和凋亡，并且仍然缺乏有效的治疗方法。通过体细胞重编程获得的多能干细胞（诱导多能干细胞，iPS细胞）与胚胎干细胞（胚胎干细胞，ES细胞）相似，具有无限增殖、分化和记忆特性。来自iPS细胞的视网膜细胞已被用于细胞移植治疗视网膜疾病、研究视网膜退行性疾病的发病机制和药物毒性评估。这可能为未来治疗视网膜退行性疾病提供新的思路和方法。
