Department of Internal Medicine and Ageing, University of Bologna, Italy.
Med Hypotheses. 2012 Oct;79(4):468-70. doi: 10.1016/j.mehy.2012.06.024. Epub 2012 Jul 15.
A consolidated therapy for "idiopathic" acute disorders of the inner ear, including Meniere's Disease (MD), does not exist despite the long-lasting and widespread attempts: this lack is strictly linked to pathogenic uncertainties. According to the theoretical model that our group developed and tested over the years, a possible cause of labyrinthine damage could be identified in systemic hemodynamic changes followed by an abnormal peripheral vasoconstriction: the latter could be responsible for a more or less prolonged ischemia able to threaten a highly energy-requiring and complicated organ as the inner ear. A possible way to treat MD attacks - as well as other inner ear disorders that possibly share the same origin - according to our model should be addressed to modulate the peripheral circulation and to maintain the balance of ion exchange, acting both on systemic hemodynamics and on cell and organelle membranes. Despite the absence of such a proposal in the English literature, a reliable solution could derive from the supplementation of the intake of a nutritional principle as Omega-3 (omega-3) polyunsaturated fatty acids (PUFAs) that seem to theoretically fulfil all the requirements necessary to achieve a homeostasis of the inner ear.
尽管人们进行了长期而广泛的尝试，但对于包括梅尼埃病 (MD) 在内的“特发性”内耳急性疾病，并没有一种综合的治疗方法：这种缺乏严格地与病因不确定性有关。根据我们小组多年来开发和测试的理论模型，可以确定迷路损伤的一个可能原因是全身性血液动力学变化后出现异常的外周血管收缩：后者可能导致或多或少的长时间缺血，从而威胁到内耳这个高能量需求且复杂的器官。根据我们的模型，治疗 MD 发作的一种可能方法（以及其他可能具有相同起源的内耳疾病）应该是调节外周循环并维持离子交换平衡，既作用于全身血液动力学，也作用于细胞和细胞器膜。尽管在英文文献中没有这样的建议，但一个可靠的解决方案可能源于补充摄入一种营养物质，如欧米伽 3（omega-3）多不饱和脂肪酸 (PUFAs)，它们似乎从理论上满足了内耳内稳态所需的所有必要条件。
