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内质网：一种感知细胞应激的传感器，可调节免疫反应。

The endoplasmic reticulum: a sensor of cellular stress that modulates immune responses.

机构信息

Dept. of Biochemistry, University of Lausanne, 155 Ch. Des Boveresses, Epalinges 1066, Switzerland.

出版信息

Microbes Infect. 2012 Nov;14(14):1293-300. doi: 10.1016/j.micinf.2012.07.005. Epub 2012 Jul 16.

DOI:10.1016/j.micinf.2012.07.005
PMID:22800981
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7110899/
Abstract

Many inflammatory and infectious diseases are characterized by the activation of signaling pathways steaming from the endoplasmic reticulum (ER). These pathways, primarily associated with loss of ER homeostasis, are emerging as key regulators of inflammation and infection. Recent advances shed light on the mechanisms linking ER-stress and immune responses.

摘要

许多炎症和传染病的特征是激活来自内质网 (ER) 的信号通路。这些通路主要与 ER 稳态的丧失有关，它们正在成为炎症和感染的关键调节剂。最近的进展揭示了 ER 应激与免疫反应之间的联系机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef67/7110899/6d5964e1348b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef67/7110899/b5a3267ff607/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef67/7110899/1edb59976b4a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef67/7110899/6d5964e1348b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef67/7110899/b5a3267ff607/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef67/7110899/1edb59976b4a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef67/7110899/6d5964e1348b/gr3.jpg

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2
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3
Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis.
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Biomolecules. 2021 Oct 13;11(10):1509. doi: 10.3390/biom11101509.
4
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5
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