Department of Pneumoconiosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, China.
J Cardiovasc Med (Hagerstown). 2012 Nov;13(11):684-90. doi: 10.2459/JCM.0b013e328356a432.
Gamma glutamyltransferase (GGT) has attracted great interest as a potential novel marker of cardiovascular risk. However, its association with coronary artery calcification (CAC) score-determined coronary artery atherosclerosis is unknown. This study was designed to assess the association of GGT with CAC score.
Participants, 311 asymptomatic men and 220 asymptomatic women who underwent evaluation of CAC by cardiac computed tomography, were retrospectively investigated. Correlation and logistic regression analysis were used to assess the association of GGT with CAC score and other variables.
Women but not men with higher GGT had a higher incidence of CAC score above 100 and a higher prevalence of metabolic syndrome (P = 0.012 and 0.007, respectively). GGT was positively correlated with C-reactive protein (CRP) in women (r = 0.336, P < 0.001). GGT was independently associated with the incidence of CAC score above 100 in women [odds ratio (OR) 1.228, 95% confidence interval (CI) 1.206-1.252, P = 0.001] but not in men.
In asymptomatic women, GGT is independently and positively associated with CAC score and it can be useful as a provisional new risk factor for CAC. Additionally, metabolic syndrome and CRP may be the mediators of the mechanisms by which GGT increases CAC in asymptomatic women.
γ-谷氨酰转移酶（GGT）作为心血管风险的潜在新型标志物引起了广泛关注。然而，其与冠状动脉钙化（CAC）评分所确定的冠状动脉粥样硬化的相关性尚不清楚。本研究旨在评估 GGT 与 CAC 评分的相关性。
回顾性调查了 311 名无症状男性和 220 名无症状女性参与者，他们均接受了心脏计算机断层扫描评估 CAC。采用相关性和逻辑回归分析来评估 GGT 与 CAC 评分和其他变量的相关性。
女性而非男性中，GGT 水平较高者 CAC 评分超过 100 的发生率更高，且代谢综合征的患病率更高（分别为 P=0.012 和 0.007）。GGT 与女性的 C 反应蛋白（CRP）呈正相关（r=0.336，P<0.001）。GGT 与女性 CAC 评分超过 100 的发生率独立相关[比值比（OR）为 1.228，95%置信区间（CI）为 1.206-1.252，P=0.001]，但与男性无关。
在无症状女性中，GGT 与 CAC 评分独立且呈正相关，可作为 CAC 的一种有用的暂定新危险因素。此外，代谢综合征和 CRP 可能是 GGT 增加无症状女性 CAC 的机制的中介物。
