[北京社区居民血清尿酸与臂踝脉搏波速度的关系]

[Association between serum uric acid and brachial ankle pulse wave velocity in Beijing community residents].

作者信息

Ma Wei, Yang Ying, Qi Li-tong, Zhao Feng, Zhang Bao-wei, Meng Lei, Zhang Yan, Jiang Jie, Li Jian-ping, Zhu Sai-nan, Wang Shu-yu, Huo Yong

机构信息

Department of Cardiology, Peking University First Hospital, Beijing 100034, China.

出版信息

Zhonghua Xin Xue Guan Bing Za Zhi. 2012 Mar;40(3):204-8.

PMID:22801264

Abstract

OBJECTIVE

To observe the relationship between serum uric acid and brachial ankle pulse wave velocity (ba-PWV) in Beijing community individuals.

METHODS

This epidemiological survey was performed in residents of two communities from Shijingshan District in Beijing from 2007 to 2008. Cardiovascular risk factors and ba-PWV were measured. Two thousand five hundred and forty three individuals with both ba-PWV and serum uric acid measurements were included. Ba-PWV ≥ 1400 cm/s was defined as abnormal. The individuals were divided into four groups (Q1, Q2, Q3 and Q4 group) according to the gender-specific quartiles of serum uric acid. Univariate logistic regression was used to evaluate the relation between various cardiovascular risk factors and ba-PWV abnormality. Multivariate logistic regression was used to evaluate the relation between serum uric acid and ba-PWV abnormality after adjusting for other cardiovascular risk factors.

RESULTS

Body mass index, triglyeride and prevalence of hypertension increased with increasing levels of serum uric acid (all P < 0.01). Univariate logistic regression analysis showed that age, gender, smoking, hypertension, systolic blood pressure, diastolic blood pressure, diabetes, body mass index, total cholesterol, triglyeride and estimated glomerular filtration rate were related with ba-PWV abnormality (all P < 0.01). Compared with Q1 group, ba-PWV abnormality OR value of Q4 group was 1.73 (95%CI: 1.34 - 2.22, P < 0.01). Multivariate logistic regression revealed that ba-PWV abnormality OR value of Q4 group was 1.66 (95%CI: 1.16 - 2.37, P < 0.01 ) after adjusting for age, gender, smoking, hypertension, systolic blood pressure, diastolic blood pressure, diabetes, body mass index, total cholesterol, triglyeride and estimated glomerular filtration rate when compared with Q1 group and OR values were 1.55 (95%CI: 0.88 - 2.74, P > 0.05) and 1.65 (95%CI: 1.04 - 2.64, P < 0.05) in male and female respectively.

CONCLUSION

Increased serum uric acid was independently associated with ba-PWV abnormality in Beijing community residents.

摘要

目的

观察北京社区人群血清尿酸与臂踝脉搏波速度（ba-PWV）之间的关系。

方法

2007年至2008年对北京市石景山区两个社区的居民进行了这项流行病学调查。测量心血管危险因素和ba-PWV。纳入2543例同时测量了ba-PWV和血清尿酸的个体。ba-PWV≥1400cm/s被定义为异常。根据血清尿酸的性别特异性四分位数将个体分为四组（Q1、Q2、Q3和Q4组）。采用单因素logistic回归评估各种心血管危险因素与ba-PWV异常之间的关系。采用多因素logistic回归评估在调整其他心血管危险因素后血清尿酸与ba-PWV异常之间的关系。

结果

体重指数、甘油三酯和高血压患病率随血清尿酸水平升高而增加（均P<0.01）。单因素logistic回归分析显示，年龄、性别、吸烟、高血压、收缩压、舒张压、糖尿病、体重指数、总胆固醇、甘油三酯和估算肾小球滤过率与ba-PWV异常有关（均P<0.01）。与Q1组相比，Q4组ba-PWV异常的OR值为1.73（95%CI：1.34-2.22，P<0.01）。多因素logistic回归显示，与Q1组相比，在调整年龄、性别、吸烟、高血压、收缩压、舒张压、糖尿病、体重指数、总胆固醇、甘油三酯和估算肾小球滤过率后，Q4组ba-PWV异常的OR值为1.66（95%CI：1.16-2.37，P<0.01），男性和女性的OR值分别为1.55（95%CI：0.88-2.74，P>0.05）和1.65（95%CI：1.04-2.64，P<0.05）。