Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Gangnam-gu, Seoul, 135-710, Korea.
Ann Nucl Med. 2012 Nov;26(9):715-22. doi: 10.1007/s12149-012-0633-0. Epub 2012 Jul 17.
To investigate the effects of variable measurement methods on mean and maximum SUV ratios of 18F-FDG uptake in carotid arteries.
18F-FDG PET/CT images of 74 subjects with carotid plaque were analyzed for mean and maximum target-to-background ratio (TBR) of uptake. Agreement was analyzed between TBR scores obtained using different vessel coverage and slice skipping.
Mean TBR was increased by extending coverage from common carotid artery (CCA; 1.25) to carotid artery (CA; 1.33) and inclusion of ascending aorta (CA/AA; 1.34). Maximum TBR was increased from 1.47 to 1.54 and 1.61 by respective extensions. Both mean and maximum TBR were closely correlated between vessels. ICC and Kappa statistics revealed near perfect agreement between TBR obtained using every 2 or 3 segments and that without sipping. Bland-Altman plots showed bias by slice skipping to remain small, particularly for mean TBR. Finally, high correlations were displayed between mean and maximum TBR.
Analysis of mean and maximum arterial 18F-FDG uptake in patients with carotid plaque is likely to benefit from extending coverage to segments above and below the CCA. The extra burden of measurement, in turn, can be lightened by skipping up to every 2 of 3 slices without compromising accuracy of results.
研究不同测量方法对颈动脉 18F-FDG 摄取的平均和最大 SUV 比值的影响。
对 74 例颈动脉斑块患者的 18F-FDG PET/CT 图像进行分析，以获得摄取的平均和最大靶与背景比（TBR）。分析了使用不同血管覆盖范围和切片跳跃进行 TBR 评分时的一致性。
从颈总动脉（CCA；1.25）扩展到颈动脉（CA；1.33）并包括升主动脉（CA/AA；1.34），平均 TBR 增加。最大 TBR 分别从 1.47 增加到 1.54 和 1.61。平均和最大 TBR 在血管之间密切相关。ICC 和 Kappa 统计数据显示，使用每 2 或 3 个节段和不跳跃获得的 TBR 之间具有近乎完美的一致性。Bland-Altman 图显示，由于切片跳跃引起的偏差较小，特别是对于平均 TBR。最后，平均和最大 TBR 之间显示出高度相关性。
分析颈动脉斑块患者的动脉 18F-FDG 摄取的平均和最大摄取量可能受益于将覆盖范围扩展到 CCA 上下的节段。反过来，通过每 2 个或 3 个切片跳跃可以减轻测量的额外负担，而不会影响结果的准确性。
