Blomberg Björn A, Akers Scott R, Saboury Babak, Mehta Nehal N, Cheng Gang, Torigian Drew A, Lim Esther, Del Bello Catherine, Werner Thomas J, Alavi Abass
Perelman School of Medicine at the University of Pennsylvania, USA.
Nucl Med Commun. 2013 Sep;34(9):860-7. doi: 10.1097/MNM.0b013e3283637512.
The aim of this study was to determine the ideal circulation time of fluorine-18 fluorodeoxyglucose (F-FDG) in order to detect and quantify atherosclerotic plaque inflammation with PET computed tomography (CT) imaging.
Fifteen patients underwent multiple time-point imaging at ∼60, 120, and 180 min after F-FDG administration. For each time point, global assessment of aortic and carotid F-FDG uptake was determined qualitatively by visual assessment and semiquantitatively by calculation of the mean and maximum standardized uptake values (SUV) and the corresponding target-to-background ratio (TBR).
Delayed imaging achieved significant improvement in visualization of atherosclerotic plaque inflammation [Friedman's χ statistic (d.f.=2, n=15)=24.13, P<0.001, Kendall's W=0.80]. This observation was confirmed by semiquantitative image analysis. At 1 h, the aortic and carotid SUVmean-calculated TBR was 1.05 [95% confidence interval (CI)=0.98, 1.11] and 0.88 (95% CI=0.81, 0.96), respectively. At 3 h, the TBR significantly increased to 1.57 (95% CI=1.28, 1.86; P=0.001) for the aorta and to 1.61 (95% CI=1.36, 1.87; P<0.001) for the carotid arteries. SUVmax-calculated TBRs showed a similar increase over time.
One- and 2-h F-FDG PET CT imaging is suboptimal for global assessment of atherosclerotic plaque inflammation compared with imaging at 3 h. Our data support the utilization of 3-h delayed imaging to obtain optimal data for the detection and quantification of atherosclerotic plaque inflammation in human arteries.
本研究旨在确定氟-18氟脱氧葡萄糖（F-FDG）的理想循环时间，以便通过正电子发射断层扫描（PET）计算机断层扫描（CT）成像检测和量化动脉粥样硬化斑块炎症。
15名患者在注射F-FDG后约60、120和180分钟接受了多个时间点的成像。对于每个时间点，通过视觉评估对主动脉和颈动脉F-FDG摄取进行整体定性评估，并通过计算平均和最大标准化摄取值（SUV）以及相应的靶本底比值（TBR）进行半定量评估。
延迟成像在动脉粥样硬化斑块炎症的可视化方面取得了显著改善[弗里德曼χ统计量（自由度=2，n=15）=24.13，P<0.001，肯德尔W=0.80]。半定量图像分析证实了这一观察结果。在1小时时，主动脉和颈动脉SUVmean计算的TBR分别为1.05[95%置信区间（CI）=0.98，1.11]和0.88（95%CI=0.81，0.96）。在3小时时，主动脉的TBR显著增加至1.57（95%CI=1.28，1.86；P=0.001），颈动脉的TBR增加至1.61（95%CI=1.36，1.87；P<0.001）。SUVmax计算的TBRs随时间呈现类似的增加。
与3小时成像相比，1小时和2小时的F-FDG PET CT成像在动脉粥样硬化斑块炎症的整体评估方面并非最佳选择。我们的数据支持使用3小时延迟成像来获取用于检测和量化人体动脉粥样硬化斑块炎症的最佳数据。
