INSERM UMR 1033, University of Lyon, Hospices Civils de Lyon, Hôpital Edouard Herriot, Pavillon F, Place d'Arsonval, 69437 Lyon, France.
J Clin Endocrinol Metab. 2012 Oct;97(10):3700-8. doi: 10.1210/jc.2012-1273. Epub 2012 Jul 16.
Myostatin is expressed mainly in skeletal muscle cells and acts as an inhibitor of muscle growth and differentiation. However, data on the determinants of serum myostatin concentrations in humans are limited.
The aim of the study was to assess the correlates of serum myostatin concentrations in men.
We conducted a cross-sectional analysis of the STRAMBO cohort.
Men holding private health insurance coverage with Mutuelle de Travailleurs de la Région Lyonnaise were included in the study.
A total of 1121 male volunteers aged 20-87 yr participated in the study.
Nonfasting blood samples were collected.
We measured the association of the investigated variables with circulating myostatin levels.
Serum myostatin levels increased slightly with age until 57 yr and then decreased. Circulating myostatin levels showed circannual variation, with the highest concentration in spring. In men older than 57 yr, serum myostatin levels decreased across increasing quartiles of body mass index and of total central and peripheral fat mass (P<0.05 to <0.001). Serum myostatin levels were positively correlated with serum levels of 25-hydroxycholecalciferol (25OHD), even after adjustment for season. Average myostatin levels were 0.47 sd higher in men with 25OHD above 40 ng/ml, compared with those with 25OHD below 20 ng/ml (P<0.05). Current smokers had lower myostatin concentration. Neither current physical activity nor serum levels of PTH, testosterone, and 17β-estradiol were associated with myostatin concentrations.
In men, circulating myostatin levels show seasonal changes and are associated with age, body mass index, fat mass, smoking, and 25OHD levels.
肌肉生长抑制素（Myostatin）主要在骨骼肌细胞中表达，作为肌肉生长和分化的抑制剂。然而，人类血清肌肉生长抑制素浓度的决定因素数据有限。
本研究旨在评估男性血清肌肉生长抑制素浓度的相关因素。
我们对 STRAMBO 队列进行了横断面分析。
里昂地区工人互助会私人医疗保险覆盖范围内的男性被纳入研究。
共有 1121 名 20-87 岁的男性志愿者参加了这项研究。
采集非禁食血样。
我们测量了研究变量与循环肌肉生长抑制素水平的相关性。
血清肌肉生长抑制素水平随年龄略有增加，直到 57 岁，然后下降。循环肌肉生长抑制素水平存在年循环变化，春季浓度最高。在 57 岁以上的男性中，血清肌肉生长抑制素水平随体重指数和总中心及外周脂肪量四分位的增加而降低（P<0.05 至<0.001）。即使在调整季节因素后，血清肌肉生长抑制素水平与血清 25-羟胆钙化醇（25OHD）水平呈正相关。与 25OHD 低于 20ng/ml 的男性相比，25OHD 高于 40ng/ml 的男性平均肌肉生长抑制素水平高 0.47sd（P<0.05）。当前吸烟者的肌肉生长抑制素浓度较低。当前的体力活动以及血清甲状旁腺激素、睾酮和 17β-雌二醇水平均与肌肉生长抑制素浓度无关。
在男性中，循环肌肉生长抑制素水平存在季节性变化，与年龄、体重指数、脂肪量、吸烟和 25OHD 水平相关。
