Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, 72 Huntley Street, London, WC1E 6DD, UK.
Cell Mol Life Sci. 2013 Feb;70(4):581-97. doi: 10.1007/s00018-012-1063-9. Epub 2012 Jul 17.
The generation of specialized neural cells in the developing and postnatal central nervous system is a highly regulated process, whereby neural stem cells divide to generate committed neuronal progenitors, which then withdraw from the cell cycle and start to differentiate. Cell cycle checkpoints play a major role in regulating the balance between neural stem cell expansion and differentiation. Loss of tumor suppressors involved in checkpoint control can lead to dramatic alterations of neurogenesis, thus contributing to neoplastic transformation. Here we summarize and critically discuss the existing literature on the role of tumor suppressive pathways and their regulatory networks in the control of neurogenesis and transformation.
在中枢神经系统的发育和出生后，专门的神经细胞的产生是一个高度受调控的过程，其中神经干细胞分裂产生定向的神经元祖细胞，然后这些祖细胞退出细胞周期并开始分化。细胞周期检查点在调节神经干细胞的扩增和分化之间的平衡中起着重要作用。涉及检查点控制的肿瘤抑制因子的丧失会导致神经发生的显著改变，从而导致肿瘤转化。在这里，我们总结和批判性地讨论了关于肿瘤抑制途径及其在神经发生和转化控制中的调节网络的现有文献。
