Aguayo A J, Bray G M, Rasminsky M, Zwimpfer T, Carter D, Vidal-Sanz M
Center for Research in Neuroscience, Montreal General Hospital, Quebec, Canada.
J Exp Biol. 1990 Oct;153:199-224. doi: 10.1242/jeb.153.1.199.
The restoration of connections in the injured central nervous system (CNS) of adult mammals is hindered by the failure of axons to grow back to their natural fields of innervation. Following transection of the optic nerve of adult rodents, the guided regeneration of retinal ganglion cell (RGC) axons along a transplanted segment of peripheral nerve (PN) has shown that these neurones retain their capacities to form well-differentiated synapses in both normal and abnormal targets. The main aim of this review is to describe the anatomical and functional characteristics of some of these connections and to suggest that their terminal distribution and morphology may be the result of a persistence in these targets of molecular determinants that influence normal connectivity in the intact animal.
成年哺乳动物受损中枢神经系统（CNS）中连接的恢复受到轴突无法生长回其天然神经支配区域的阻碍。成年啮齿动物视神经横断后，视网膜神经节细胞（RGC）轴突沿移植的外周神经（PN）段的引导再生表明，这些神经元在正常和异常靶标中均保留形成高度分化突触的能力。本综述的主要目的是描述其中一些连接的解剖学和功能特征，并表明它们的终末分布和形态可能是这些靶标中影响完整动物正常连接的分子决定因素持续存在的结果。
