Comprehensive Pneumology Center, Ludwig Maximilians University Munich and Helmholtz Zentrum München, Max-Lebsche-Platz 31, Munich, Germany.
Proc Am Thorac Soc. 2012 Jul;9(3):111-6. doi: 10.1513/pats.201203-023AW.
Transforming growth factor-β (TGF-β) is extensively involved in the development of fibrosis in different organs. Overproduction or potentiation of its profibrotic effects leads to an aberrant wound healing response during the initiation of fibrotic processes. Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating disease, in which TGF-β\x{2013}induced disturbances of the homeostatic microenvironment are critical to promote cell activation, migration, invasion, or hyperplastic changes. In addition, excess extracellular matrix production contributes in a major way to disease pathogenesis. For this reason, this review will focus on discussing novel data and highlight growing interest in deepening the understanding of the profibrotic role of TGF-β and its direct or indirect targeting for disease modulation.
转化生长因子-β（TGF-β）广泛参与不同器官的纤维化发展。其促纤维化作用的过度产生或增强导致纤维化过程开始时异常的伤口愈合反应。特发性肺纤维化（IPF）是一种慢性、破坏性疾病，其中 TGF-β诱导的稳态微环境紊乱对于促进细胞激活、迁移、侵袭或增生性改变至关重要。此外，细胞外基质的过度产生在很大程度上导致了疾病的发病机制。因此，本综述将重点讨论新的数据，并强调加深对 TGF-β的促纤维化作用及其对疾病调节的直接或间接靶向作用的理解的日益增长的兴趣。
