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病理学中基因组学的未来。

The future of genomics in pathology.

作者信息

Wall Dennis P, Tonellato Peter J

出版信息

F1000 Med Rep. 2012;4:14. doi: 10.3410/M4-14. Epub 2012 Jul 2.

DOI:10.3410/M4-14
PMID:22802873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3391753/
Abstract

The recent advances in technology and the promise of cheap and fast whole genomic data offer the possibility to revolutionise the discipline of pathology. This should allow pathologists in the near future to diagnose disease rapidly and early to change its course, and to tailor treatment programs to the individual. This review outlines some of these technical advances and the changes needed to make this revolution a reality.

摘要

技术上的最新进展以及廉价且快速的全基因组数据所带来的前景,为病理学学科带来了变革的可能性。这有望使病理学家在不久的将来能够快速且早期地诊断疾病,从而改变疾病进程,并为个体量身定制治疗方案。本综述概述了其中的一些技术进展以及为实现这一变革所需做出的改变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb61/3391753/f4eeda5c37d5/medrep-04-14-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb61/3391753/f4eeda5c37d5/medrep-04-14-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb61/3391753/f4eeda5c37d5/medrep-04-14-g001.jpg

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1
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2
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Am J Clin Pathol. 2011 May;135(5):668-72. doi: 10.1309/AJCP9GDNLWB4GACI.
3
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Front Oncol. 2020 Mar 11;10:236. doi: 10.3389/fonc.2020.00236. eCollection 2020.
4
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5
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Mol Cell Proteomics. 2016 Aug;15(8):2525-36. doi: 10.1074/mcp.O116.059253. Epub 2016 Apr 20.
6
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IMA Fungus. 2014 Jun;5(1):135-40. doi: 10.5598/imafungus.2014.05.01.13. Epub 2014 Jun 19.
7
Impact of pyrrolidine-bispyrrole DNA minor groove binding agents and chirality on global proteomic profile in Escherichia Coli.吡咯并吡咯二酮 DNA 小沟结合剂和手性对大肠杆菌全局蛋白质组图谱的影响。
Proteome Sci. 2013 May 23;11(1):23. doi: 10.1186/1477-5956-11-23.
Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors.
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4
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5
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