环磷酰胺注射后抗肿瘤耐药性的动态变化
Dynamics of antitumor resistance after cyclophosphamide injection.
作者信息
Terpinskaya T I
机构信息
Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Belarus.
出版信息
Bull Exp Biol Med. 2012 Mar;152(5):613-4. doi: 10.1007/s10517-012-1589-8.
Antitumor resistance decreased in mice 24 h after injection of cyclophosphamide in a dose of 100 mg/kg. This was seen from more rapid growth of Ehrlich's ascitic carcinoma transplanted intraperitoneally 24 h after cyclophosphamide injection and 17% reduction of the lifespan of mice with tumors. Three, 7, 10, 14, and 22 days after cyclophosphamide injection, the antitumor resistance increased and the lifespan of animals with Ehrlich's ascitic carcinoma transplanted at the corresponding periods increased by 20, 14, 42, 29, and 36%, respectively, in comparison with mice with transplanted tumor not injected with the drug. Injection of cyclophosphamide 1 day after tumor transplantation prolonged of the lifespan of animals with tumors by 76%.
注射剂量为100mg/kg的环磷酰胺24小时后，小鼠的抗肿瘤抵抗力下降。这表现为环磷酰胺注射24小时后腹腔移植的艾氏腹水癌生长更快，且荷瘤小鼠的寿命缩短了17%。环磷酰胺注射后3天、7天、10天、14天和22天，抗肿瘤抵抗力增强，与未注射药物的移植肿瘤小鼠相比，在相应时期移植艾氏腹水癌的动物寿命分别延长了20%、14%、42%、29%和36%。肿瘤移植1天后注射环磷酰胺使荷瘤动物的寿命延长了76%。
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