Diatroptov M E
Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia.
Bull Exp Biol Med. 2012 Mar;152(5):630-2. doi: 10.1007/s10517-012-1594-y.
Several-day rhythmic changes in the lymphocyte subpopulation composition and peripheral blood levels of IL-2 and hydrocortisone were studied in healthy men. The samples were collected daily at 8.00. A 4-day rhythm of hydrocortisone secretion manifested synchronously in different individuals. Rhythmic changes in IL-2 level, T-helper/T-suppressor cytotoxic lymphocyte index, and percentage of NK cells in the peripheral blood related to the hormone levels were detected. Rhythmic changes in these parameters should be taken into consideration when evaluating the hormonal profiles and immunological status of healthy subjects and development of methods for correction of abnormalities.
在健康男性中研究了淋巴细胞亚群组成以及白细胞介素-2（IL-2）和氢化可的松外周血水平的数日节律变化。样本于每天8点采集。氢化可的松分泌的4日节律在不同个体中同步显现。检测到外周血中IL-2水平、辅助性T细胞/抑制性细胞毒性淋巴细胞指数以及自然杀伤细胞百分比与激素水平相关的节律变化。在评估健康受试者的激素谱和免疫状态以及制定异常情况校正方法时，应考虑这些参数的节律变化。
