Zhai Xue-Qin, Liu Hao, Wang Xiao-Feng
Department of Chinese Medicine, Xinjiang Medical University, Urumqi 830011.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Apr;32(4):478-81.
To study the correlation between the Chinese medicine (CM) syndrome types of the Uighur and Han people and levels of blood lipids and fibrinogen in premature coronary heart disease (PCHD) patients.
Recruited were 196 Uighur and 189 Han patients with PCHD first confirmed by coronary angiography at the Heart Center of First Affiliated Hospital of Xinjiang Medical University and Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University. Another 60 healthy volunteers were recruited as the healthy control group. CM syndromes were typed by physicians or those having higher professional titles at the cardiac internal medicine. The contents of triglyceride (TG) and total cholesterol (TC) were detected using oxidase method. The high-density lipoprotein cholesterol (HDL-C) level was detected using chemical modification enzymic method. The low-density lipoprotein cholesterol (LDL-C) level was detected using selective dissolution. The fibrinogen (FIB) level was detected using Clauss congeal principle.
The CM syndrome types of Uighurs were sequenced as filthy turbidity and phlegm obstruction syndrome (82 cases, 21.3%) > qi deficiency and blood stasis syndrome (61 cases, 15.84%) >cold accumulation in Xin meridian syndrome (39 cases, 10.13%) >Xin-Shen yin deficiency syndrome (14 cases, 3. 63%). The CM syndrome types of the Han nationality were sequenced as qi deficiency and blood stasis syndrome (69 cases, 17.92%) >filthy turbidity and phlegm obstruction syndrome (67 cases, 17.40%) > cold accumulation in Xin meridian syndrome (42 cases, 10.91%) > Xin-Shen yin deficiency syndrome (11 cases, 2.86%). There was no statistical difference in the syndrome type distribution between the two groups (P >0.05). Compared with the healthy control group, the levels of TG, LDL-C, and FIB increased, and the HDL-C level decreased in patients of filthy turbidity and phlegm obstruction syndrome and qi deficiency and blood stasis syndrome of the patient group. The HDL-C level decreased in the Uighur patients of Xin-Shen yin deficiency syndrome, showing statistical difference (P < 0.01, P < 0.05). Compared with the Han people of the same syndrome type, the TG level increased and the HDL-C level decreased in the Uighur patients of filthy turbidity and phlegm obstruction syndrome. The FIB level increased in the Uighur patients of qi deficiency and blood stasis syndrome with statistical difference (P<0.05). In the Uighur patients, filthy turbidity and phlegm obstruction syndrome was positively correlated with TG (r=0.469) and FIB (r=0.464), and negatively correlated with HDL-C (r=-0.382). Qi deficiency and blood stasis syndrome was positively correlated with FIB (r=0.72) with statistical difference (P<0.01, P<0.05). In the Han patients, filthy turbidity and phlegm obstruction syndrome was positively correlated with TG (r=0.445) and FIB (r=0.372), and negatively correlated with HDL-C (r=-0.37). Qi deficiency and blood stasis syndrome was positively correlated with TG (r=0.471) and FIB (r=0.459) with statistical difference (P<0.01, P<0.05).
CM syndrome types were correlated with TG, HDL-C, and FIB in PCHD Han and Uighur patients.
研究维吾尔族与汉族早发冠心病（PCHD）患者的中医证型与血脂及纤维蛋白原水平的相关性。
选取新疆医科大学第一附属医院心脏中心及新疆医科大学附属中医医院经冠状动脉造影首次确诊为PCHD的196例维吾尔族患者和189例汉族患者。另招募60名健康志愿者作为健康对照组。由心内科医师或具有较高职称者进行中医证型分型。采用氧化酶法检测甘油三酯（TG）和总胆固醇（TC）含量。采用化学修饰酶法检测高密度脂蛋白胆固醇（HDL-C）水平。采用选择性溶解法检测低密度脂蛋白胆固醇（LDL-C）水平。采用Clauss凝固原理检测纤维蛋白原（FIB）水平。
维吾尔族中医证型排序为秽浊痰阻证（82例，21.3%）＞气虚血瘀证（61例，15.84%）＞寒凝心脉证（39例，10.13%）＞心肾阴虚证（14例，3.63%）。汉族中医证型排序为气虚血瘀证（69例，17.92%）＞秽浊痰阻证（67例，17.40%）＞寒凝心脉证（42例，10.91%）＞心肾阴虚证（11例，2.86%）。两组证型分布差异无统计学意义（P＞0.05）。与健康对照组相比，患者组秽浊痰阻证和气虚血瘀证患者的TG、LDL-C及FIB水平升高，HDL-C水平降低。心肾阴虚证维吾尔族患者HDL-C水平降低，差异有统计学意义（P＜0.01，P＜0.05）。秽浊痰阻证维吾尔族患者与同证型汉族患者相比，TG水平升高，HDL-C水平降低。气虚血瘀证维吾尔族患者FIB水平升高，差异有统计学意义（P＜0.05）。维吾尔族患者中，秽浊痰阻证与TG（r=0.469）、FIB（r=0.464）呈正相关，与HDL-C（r=-0.382）呈负相关。气虚血瘀证与FIB（r=0.72）呈正相关，差异有统计学意义（P＜0.01，P＜0.05）。汉族患者中，秽浊痰阻证与TG（r=0.445）、FIB（r=0.372）呈正相关，与HDL-C（r=-0.37）呈负相关。气虚血瘀证与TG（r=0.471）、FIB（r=0.459）呈正相关，差异有统计学意义（P＜0.01，P＜0.05）。
PCHD汉族和维吾尔族患者的中医证型与TG、HDL-C及FIB相关。
