Zhou Yu-Ping, Hu Yuan-Hui, Wu Hua-Qin
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Sep;29(9):798-801.
To explore the relationship of Chinese medicine syndromes with heart function and peripheral blood stem cells (PBSCs) count in patients with ischemic heart failure (IHF).
Clinical materials of 208 inpatients with IHF were collected and the characteristics of their Chinese medicine syndromes were summarized, the number of PBSC was counted with flow cytometer, and the differences of left ventricular ejection fraction (LVEF), N-terminal brain natriuretic peptide (NT-proBNP) and PBSC count related to various syndrome factors and syndrome types were compared using One-way ANOVA.
LVEF >50% was found in patients with syndromes of qi-deficiency, yin-deficiency, turbid-phlegm and blood-stasis, while <50% in those of yang-deficiency and fluid-retention, showing significant differences between the former four syndromes and the latter two syndromes. Compared them with syndromes of qi-deficiency, yin-deficiency, turbid-phlegm and blood-stasis, NT-proBNP in the yang deficiency group and water retention group was higher (P<0.01); the PBSC count in patients with yang-deficiency syndrome factor was the least, which was significantly different to that in patients with the former four syndromes (P<0.01, P<0.05), but it was insignificantly different to that with water-retention; LVEF >50% in syndrome types of Xin-Fei qi-deficiency, deficiency of qi and yin, qi-deficiency with blood-stasis and phlegm accumulation in Fei, but <50% in syndrome types of Xin-Shen yang-deficiency and yang-deficiency with water-retention. Compared them with syndrome types of Xin-Fei qi-deficiency, deficiency of qi and yin, qi-deficiency with blood-stasis and phlegm accumulation in Fei, the difference was statistically significant (P<0.05, P<0.01); The highest level of NT-proBNP was shown in syndrome type of yang-deficiency with water-retention, the secondary was in Xin-Shen yang-deficiency, and all showed significant differences as compared with that in other syndrome types (P<0.05); while difference of PBSC count in patients with various syndrome types showed insignificance (P>0.05).
Chinese medicine syndrome is correlated with heart function and PBSC count in patients with IHF, and the PBSC count in patients with characteristics of yang-deficiency syndrome is lower.
探讨缺血性心力衰竭（IHF）患者中医证候与心功能及外周血干细胞（PBSCs）计数的关系。
收集208例IHF住院患者的临床资料，总结其中医证候特点，采用流式细胞仪计数PBSC数量，运用单因素方差分析比较左心室射血分数（LVEF）、N末端脑钠肽（NT-proBNP）及PBSC计数在不同证候要素及证型间的差异。
气虚、阴虚、痰浊、血瘀证患者LVEF>50%，阳虚、水饮证患者LVEF<50%，前四证与后两证比较差异有统计学意义。阳虚组和水饮组NT-proBNP高于气虚、阴虚、痰浊、血瘀证组（P<0.01）；阳虚证要素患者PBSC计数最少，与前四证患者比较差异有统计学意义（P<0.01，P<0.05），与水饮证患者比较差异无统计学意义；心肺气虚、气阴两虚、气虚血瘀、痰热壅肺证型患者LVEF>50%，心肾阳虚、阳虚水泛证型患者LVEF<50%，两组比较差异有统计学意义（P<0.05，P<0.01）；阳虚水泛证型NT-proBNP水平最高，心肾阳虚证次之，与其他证型比较差异有统计学意义（P<0.05）；各证型患者PBSC计数比较差异无统计学意义（P>0.05）。
IHF患者中医证候与心功能及PBSC计数相关，阳虚证特征患者PBSC计数较低。
