Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea.
Psychophysiology. 2012 Sep;49(9):1290-7. doi: 10.1111/j.1469-8986.2012.01409.x. Epub 2012 Jul 16.
The effects of stress, which varies throughout an academic year, on proinflammatory and antiinflammatory cytokines were examined in 44 medical students. This was tested by comparing stimulated cytokines during a baseline period, stress period, and poststress vacation period. During the stress period, compared with the baseline period, levels of IL-6 were reduced, while levels of IL-10 were elevated. During the poststress vacation period, compared with the stress period, levels of IL-6 and TNF-α were increased. However, the changes in stress-related psychological and physiological variables were not significantly associated with changes in levels of proinflammatory and antiinflammatory cytokines. These results suggest that vacation is more likely to have a counterstress effect on proinflammatory cytokines than on an antiinflammatory cytokine and that a stressor may affect changes in immune function independently of self-reported stress.
本研究旨在探讨医学专业学生整个学年中压力变化对促炎细胞因子和抗炎细胞因子的影响。研究通过比较基线期、压力期和应激后假期期的刺激细胞因子来检测。与基线期相比，压力期的 IL-6 水平降低，而 IL-10 水平升高。与压力期相比，应激后假期期的 IL-6 和 TNF-α 水平升高。然而，应激相关心理和生理变量的变化与促炎和抗炎细胞因子水平的变化没有显著相关性。这些结果表明，假期对促炎细胞因子的抗应激作用可能比抗炎细胞因子更强，应激源可能独立于自我报告的应激影响免疫功能的变化。
