计算机建模研究转酮醇酶样蛋白 TKTL1，它是某些肿瘤组织的标志物。

Computer modeling of transketolase-like protein, TKTL1, a marker of certain tumor tissues.

机构信息

Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119991, Russia.

出版信息

Biochemistry (Mosc). 2012 Mar;77(3):296-9. doi: 10.1134/S000629791203008X.

DOI:10.1134/S000629791203008X

Abstract

A computer model of the spatial structure of transketolase-like protein (TKTL1), a marker of certain tumor tissues, has been constructed using the known spatial structure of transketolase found in normal human tissues. The structure of the two proteins at all levels of their organization has also been compared. On the basis of the revealed differences in structures of these proteins, we assume it is unlikely that TKTL1 can be a thiamine diphosphate-dependent protein capable of catalyzing the transketolase reaction.

摘要

已经使用在正常人体组织中发现的转酮醇酶的已知空间结构构建了转酮醇酶样蛋白（TKTL1）的空间结构的计算机模型，TKTL1 是某些肿瘤组织的标志物。还比较了这两种蛋白质在其所有组织层次上的结构。基于这些蛋白质结构的差异，我们假设 TKTL1 不太可能是一种依赖硫胺素二磷酸的、能够催化转酮醇酶反应的蛋白质。