诱导 Dahl 大鼠患高血压
Hypertension induction in Dahl rats.
作者信息
Flowers S W, Jamal I A, Bogden J, Thanki K, Ballester H
机构信息
University of Medicine and Dentistry of New Jersey, Maplewood.
出版信息
J Natl Med Assoc. 1990 Dec;82(12):837-40.
There is experimental and epidemiologic evidence that some minerals and trace elements play a role in hypertension. We designed an experiment in which salt and water sources were manipulated to examine the possible impact of this relationship. A strain of rats (Dahl rats) known to become hypertensive with sodium chloride ingestion was used to study the effect of salt source and water source on the induction of hypertension. The group on tap water and table salt had blood pressures (184 mmHg +/- 19) significantly higher than every other group in the experiment. The experimental animals receiving tap water plus table salt had the highest blood pressure levels, although they consumed the lowest quantity of sodium. Analysis of the tap water samples showed "soft water" by analysis of calcium and magnesium concentration. This could adversely affect blood pressure. The relatively high magnesium concentration in sun evaporated sea salt may play a protective role in hypertension induction. The zinc and copper present in tap water may play an exacerbating role.
有实验和流行病学证据表明，某些矿物质和微量元素在高血压中起作用。我们设计了一项实验，对盐和水源进行操控，以检验这种关系可能产生的影响。一种已知摄入氯化钠会患高血压的大鼠品系（达尔大鼠）被用于研究盐源和水源对高血压诱发的影响。饮用自来水和食用食盐的组的血压（184 mmHg ± 19）显著高于实验中的其他所有组。接受自来水加食盐的实验动物血压水平最高，尽管它们摄入的钠量最低。对自来水样本的分析通过钙和镁浓度分析显示为“软水”。这可能对血压产生不利影响。日晒蒸发海盐中相对较高的镁浓度可能在高血压诱发中起保护作用。自来水中的锌和铜可能起加剧作用。
Zotero 插件