Department of Human Oncology and Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Int Rev Immunol. 2012 Aug;31(4):267-78. doi: 10.3109/08830185.2012.698337.
CD40 ligation has been shown to induce antitumor effects in mice and cancer patients. Most of the studies have focused on the ability of an agonistic anti-CD40 mAb to either directly kill CD40-positive tumor cells or activate T-cell immune responses. In this review the authors focus on the ability of CD40 ligation to activate antitumor effector mechanisms of the cells of innate immunity such as macrophages and NK cells.
CD40 交联已被证明可在小鼠和癌症患者中诱导抗肿瘤作用。大多数研究都集中在激动性抗 CD40 mAb 直接杀死 CD40 阳性肿瘤细胞或激活 T 细胞免疫反应的能力上。在这篇综述中，作者重点介绍了 CD40 交联激活先天免疫细胞（如巨噬细胞和 NK 细胞）抗肿瘤效应机制的能力。
