Chelsea and Westminster Hospital, Imperial College, London, UK.
Anaesthesia. 2012 Oct;67(10):1152-7. doi: 10.1111/j.1365-2044.2012.07247.x. Epub 2012 Jul 17.
Haemorrhage remains an important cause of maternal mortality worldwide. Cell salvage carries a theoretical risk of amniotic fluid embolus syndrome and is too expensive for use in many parts of the world. To explore cheaper options, we investigated whether a leucocyte depletion filter alone removes components of pure amniotic fluid. Amniotic fluid was collected from 10 women during elective caesarean section and passed through a LeukoGuard® RS filter. Pre- and post-filtration samples were compared in the laboratory. Lamellar bodies and fetal squames were almost completely removed (filtration efficacy 96.6% and 99.9%, respectively; p<0.0001 and <0.0004), and hair was completely removed (p=0.002). Filtration had no effect on concentrations of α-fetoprotein, tissue factor or endothelin-1, or on the presence of meconium or vernix. Additional work is required to evaluate whether cell salvage using filtration alone may be useful in maternal haemorrhage in the developing world.
出血仍然是全世界产妇死亡的一个重要原因。细胞回收术有理论上的羊水栓塞综合征风险，并且在世界上许多地方都过于昂贵而无法使用。为了探索更便宜的选择，我们研究了单独使用白细胞滤器是否可以去除纯羊水的成分。在选择性剖宫产期间从 10 名妇女中收集羊水，并通过 LeukoGuard® RS 过滤器进行过滤。在实验室中比较过滤前后的样本。板层小体和胎儿鳞屑几乎完全被去除（过滤效率分别为 96.6%和 99.9%；p<0.0001 和 <0.0004），头发完全被去除（p=0.002）。过滤对α-胎蛋白、组织因子或内皮素-1的浓度，以及胎粪或胎脂的存在没有影响。需要进一步的工作来评估单独使用过滤进行细胞回收术是否可用于发展中国家的产妇出血。
