Suzuki M, Sitizyo K, Takeuchi T, Saito T
Department of Veterinary Physiology, Faculty of Agriculture, Tottori University, Japan.
Nihon Juigaku Zasshi. 1990 Oct;52(5):1077-87. doi: 10.1292/jvms1939.52.1077.
Electroencephalogram (EEG) examinations were carried out on three Japanese Black calves (1, 2 and 14 week old) affected with cerebrocortical necrosis (CCN) in order to investigate the relationship between EEG abnormalities and encephalic lesions. Some neurologic signs such as circling, astasia, convulsion and opisthotonus appeared in two of the calves (case 1 and 3). The other calf (case 2), however, showed no neurologic signs. The EEGs obtained from the two calves (case 1 and 2), in the awake state, showed constant high amplitude (50-160 microV) and slow (1-4 Hz) activity (HASA). One of these (case 1) had necrosis mainly in the right hemisphere and showed a markedly asymmetric sharp wave. On the other hand, in case 3, the EEG showed diffuse lowered activity, and almost flat in some leads. A decrease in fast activity observed in common with all three animals. These findings suggest that one of the characteristic EEG patterns of CCN patient may be HASA and decreased fast activity. Histopathologic diagnoses of the calves were CCN in various degrees. The degrees of abnormality of the EEGs seemed to accord with the seriousness of the lesions. Because the EEG obtained from the calf having no obvious neurologic signs showed an abnormal pattern, it was considered that EEG examinations in the early stages of disorders are valuable to diagnose CCN.
为了研究脑电图（EEG）异常与脑部病变之间的关系，对三头患有脑皮质坏死（CCN）的日本黑毛犊牛（分别为1周龄、2周龄和14周龄）进行了脑电图检查。其中两头犊牛（病例1和3）出现了一些神经症状，如转圈、站立不稳、抽搐和角弓反张。然而，另一头犊牛（病例2）未表现出神经症状。在清醒状态下，从这两头犊牛（病例1和2）获得的脑电图显示出持续的高振幅（50 - 160微伏）和慢波（1 - 4赫兹）活动（高振幅慢波活动，HASA）。其中一头（病例1）主要在右半球出现坏死，并显示出明显的不对称尖波。另一方面，病例3的脑电图显示弥漫性活动降低，某些导联几乎呈平线。在所有三头动物中均观察到快波活动减少。这些发现表明，CCN患者的脑电图特征性模式之一可能是高振幅慢波活动和快波活动减少。对这些犊牛的组织病理学诊断为不同程度的CCN。脑电图的异常程度似乎与病变的严重程度相符。由于从未表现出明显神经症状的犊牛获得的脑电图显示出异常模式，因此认为在疾病早期进行脑电图检查对CCN的诊断具有重要价值。
