Balázs Csaba, Türke Boglárka, Vámos Arpád
Budai Irgalmasrendi Kórház Belgyógyászat Budapest.
Orv Hetil. 2012 Jul 22;153(29):1127-31. doi: 10.1556/OH.2012.29405.
An elevated serum level of neopterin indicates the activation of the cellular immune system.
The objective was to find a correlation in autoimmune thyroid patients between neopterin levels and the clinical stage of the disease and to examine whether neopterin can predict the relapse of the disease.
Serum neopterin, thyroid stimulating hormone, free thyroxine, free triiodothyronine, anti-thyroglobulin and anti-thyroid peroxidase antibody levels were determined in 137 patients with Graves' disease (in different stages), 25 with Hashimoto's thyroiditis and 14 with toxic adenoma.
The neopterin levels were significantly higher in patients with Graves' disease (hyper-, eu-, hypothyroidism and relapsed hyperthyroidism) and Hashimoto's thyroiditis. Positive correlation was found between neopterin and anti-thyroglobulin and anti-thyroid peroxidase antibody levels, but no correlation was detected between neopterin levels and thyroid hormones, thyroid stimulating hormone values and antibodies against thyroid stimulating hormone receptors.
Higher level of serum neopterin reflects an underlying autoimmune process, and does not correlate with changes in thyroid hormone levels. Determination of neopterin level can be an important indicator in the exacerbation of autoimmune processes.
血清新蝶呤水平升高表明细胞免疫系统被激活。
目的是找出自身免疫性甲状腺疾病患者中新蝶呤水平与疾病临床分期之间的相关性，并检验新蝶呤是否能预测疾病复发。
测定了137例不同阶段的格雷夫斯病患者、25例桥本甲状腺炎患者和14例毒性腺瘤患者的血清新蝶呤、促甲状腺激素、游离甲状腺素、游离三碘甲状腺原氨酸、抗甲状腺球蛋白和抗甲状腺过氧化物酶抗体水平。
格雷夫斯病患者（甲亢、甲功正常、甲减及复发甲亢）和桥本甲状腺炎患者的新蝶呤水平显著更高。新蝶呤与抗甲状腺球蛋白及抗甲状腺过氧化物酶抗体水平呈正相关，但新蝶呤水平与甲状腺激素、促甲状腺激素值及抗促甲状腺激素受体抗体之间未检测到相关性。
血清新蝶呤水平升高反映了潜在的自身免疫过程，且与甲状腺激素水平变化无关。新蝶呤水平的测定可能是自身免疫过程加剧的一项重要指标。
