Al-Rabia Mohammed W
Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Pak J Pharm Sci. 2017 Mar;30(2(Suppl.)):607-612.
The serum concentrations of anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies are directly correlate in the induction and diagnosis of autoimmune thyroid disorders (AITDs). Therefore, the evaluation of serum anti-TPO and anti-TG antibodies in relation to thyroid function test parameters including thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4). This evaluation would be helpful in early diagnosis of abnormal thyroid function and associated autoimmune thyroid diseases. In this cross-sectional study, the serum anti-TPO, anti-TG, T3, T4 and TSH levels of 311 suspected patients of autoimmune thyroid disorders and 40 control subjects were evaluated. The data were presented as mean, ± standard deviations of the mean. Pearson correlation and chi-square tests were used to assess the correlation coefficients and significance in the contingency tables. The thyroid function test parameters in normal and AITDs suspected patients were significantly different in correlation to elevated serum levels of anti-TPO antibody. A significant association was detected between female gender and elevated levels of anti-TPO (P value = 0.047). A higher percentage of women showed elevated levels of anti-TG, but it was not statistically significant (P value= 0.107). The findings of the study reveal a strong correlation between thyroid function test and thyroid antibodies levels, elaborating the clinical importance of thyroid antibodies in clinical examination and follow-up of patients with autoimmune thyroid disorders.
抗甲状腺过氧化物酶（抗-TPO）和抗甲状腺球蛋白（抗-TG）抗体的血清浓度与自身免疫性甲状腺疾病（AITDs）的诱导和诊断直接相关。因此，要评估血清抗-TPO和抗-TG抗体与甲状腺功能测试参数的关系，这些参数包括促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）和甲状腺素（T4）。这种评估有助于早期诊断甲状腺功能异常及相关的自身免疫性甲状腺疾病。在这项横断面研究中，对311名疑似自身免疫性甲状腺疾病患者和40名对照受试者的血清抗-TPO、抗-TG、T3、T4和TSH水平进行了评估。数据以平均值±平均标准差表示。采用Pearson相关性检验和卡方检验来评估列联表中的相关系数和显著性。正常人和疑似AITDs患者的甲状腺功能测试参数与抗-TPO抗体血清水平升高显著相关。检测到女性性别与抗-TPO水平升高之间存在显著关联（P值 = 0.047）。较高比例的女性抗-TG水平升高，但无统计学意义（P值 = 0.107）。该研究结果揭示了甲状腺功能测试与甲状腺抗体水平之间的强烈相关性，阐明了甲状腺抗体在自身免疫性甲状腺疾病患者临床检查和随访中的临床重要性。
