Department of Neuroscience, Physiology and Pharmacology, University College London, UK.
Nat Rev Neurosci. 2012 Jul 18;13(8):542-55. doi: 10.1038/nrn3311.
The voltage-gated calcium channel α(2)δ and β subunits are traditionally considered to be auxiliary subunits that enhance channel trafficking, increase the expression of functional calcium channels at the plasma membrane and influence the channels' biophysical properties. Accumulating evidence indicates that these subunits may also have roles in the nervous system that are not directly linked to calcium channel function. For example, β subunits may act as transcriptional regulators, and certain α(2)δ subunits may function in synaptogenesis. The aim of this Review is to examine both the classic and novel roles for these auxiliary subunits in voltage-gated calcium channel function and beyond.
电压门控钙通道的 α(2)δ 和 β 亚基传统上被认为是辅助亚基，它们可以增强通道运输，增加质膜上功能性钙通道的表达，并影响通道的生物物理特性。越来越多的证据表明，这些亚基在神经系统中可能具有与钙通道功能没有直接联系的作用。例如，β 亚基可能充当转录调节剂，某些 α(2)δ 亚基可能在突触发生中发挥作用。本综述的目的是检查这些辅助亚基在电压门控钙通道功能及其他方面的经典和新作用。
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