Center for Biostatistics in AIDS Research, Department of Biostatistics, FXB-513 Harvard School of Public Health, Boston, MA 02115, USA.
J Neurovirol. 2012 Oct;18(5):428-33. doi: 10.1007/s13365-012-0119-9. Epub 2012 Jul 18.
The purpose of this study is to evaluate risk factors for progression from asymptomatic peripheral neuropathy (APN) to symptomatic peripheral neuropathy (SPN). Antiretroviral therapy (ART)-naïve patients initiating combination ART were followed longitudinally and screened for signs/symptoms of PN. Having APN was associated with higher odds of future SPN (odds ratio (OR) = 1.58, 95 % confidence interval (CI) = (1.08, 2.29), p = 0.027). Neurotoxic ART use was associated with increased odds of progression to SPN (OR = 2.16, 95 % CI = (1.21, 3.85), p = 0.009) while use of glucose-lowering drugs (non-insulin) was protective (OR = 0.12, 95 % CI = (0.02, 0.83), p = 0.031). Use of glucose-lowering drugs (non-insulin) may prevent progression from APN to SPN.
本研究旨在评估无症状周围神经病变（APN）向有症状周围神经病变（SPN）进展的风险因素。对开始联合抗逆转录病毒治疗（cART）的抗逆转录病毒治疗（ART）初治患者进行纵向随访，并筛查周围神经病变的体征/症状。APN 与未来 SPN 的发生几率更高相关（比值比（OR）= 1.58，95%置信区间（CI）=（1.08，2.29），p = 0.027）。神经毒性 ART 的使用与进展为 SPN 的几率增加相关（OR = 2.16，95%CI =（1.21，3.85），p = 0.009），而使用降血糖药物（非胰岛素）具有保护作用（OR = 0.12，95%CI =（0.02，0.83），p = 0.031）。使用降血糖药物（非胰岛素）可能预防 APN 向 SPN 进展。
